Innate lymphoid cells: diversity, plasticity, and unique functions in immunity. Immunity 48, 1104–1117 (2018). Article PubMed PubMed Central CAS Google Scholar Chiossone, L., Dumas, P.-Y., Vienne, M. & Vivier, E. Natural killer cells and other innate lymphoid cells in cancer. Nat....
NK cells direct the perspective approaches to cancer immunotherapy Article 15 June 2023 References Vivier, E. et al. Innate lymphoid cells: 10 years on. Cell 174, 1054–1066 (2018). Article PubMed CAS Google Scholar Colonna, M. Innate lymphoid cells: diversity, plasticity, and unique fun...
L. Addressing natural killer cell dysfunction and plasticity in cell-based cancer therapeutics. Cancers 15, 1743 (2023). Article CAS PubMed PubMed Central Google Scholar Laskowski, T. J., Biederstädt, A. & Rezvani, K. Natural killer cells in antitumour adoptive cell immunotherapy. Nat. ...
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in immune activation against abnormal cells. Different from events required for T cell activation, NK cell activation is governed by the interaction of NK rece
Cytotoxic innate lymphoid cells, conventionally known as natural killer (NK) cells, play major roles in cancer immunity largely due to their natural cytolytic and immune regulatory functions. However, due to the extensive heterogeneity and plasticity seen among NK cells, their functions have yet to ...
El Sherbiny YM, Meade JL, Holmes TD, McGonagle D, Mackie SL, Morgan AWet al. (2007). The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells.Cancer Res67: 8444–8449. CASPubMedGoogle Scholar ...
9.Cellular & Molecular Immunology(24.1)| 2024.03.05 | Development of NK cell-based cancer immunotherapies through receptor engineering.(通过受体工程开发基于 NK 细胞的癌症免疫疗法) 基于自然杀伤(NK)细胞增强的识别能力和细胞毒性...
NK细胞在免疫系统中表现出很高的细胞毒性。更改其数量或活性可能会对整体免疫力产生深远影响。他的降低让老年人群变得更容易受到感染、患癌、自身免疫疾病和神经退行性疾病等。
D) Trifunctional NK cell engagers (NKCEs) act on two activating receptors, NKp46 (via scFv) and CD16 (via Fc), and a tumor antigen (via scFv) on cancer cells. E) Immune checkpoint inhibitors (ICI) such as anti-NKG2A and anti-PD-1 can unleash NK cells, allowing an antitumor ...
We found that NK cells acquire cell-intrinsic memory-like properties, demonstrated by increased IFNγ production upon re-challenge, up to 9 weeks after endotoxemia. Strikingly, systemic inflammation reveals a latent enhancer at the ifng locus in memory-like NK cells, and blocking this, along with...