NK: Natural killer pDCs: Plasmacytoid dendritic cells mIHC: Multiple immunofluorescence PR: Partial response SD: Stable disease PD: Progressive disease THYM: Thymoma READ: Rectum adenocarcinoma DNMTs: DNA methylation transferases Tex: Exhausted CD8+ T cell ...
NKG2A (KLRC1) belongs to the NKG2 family, which has been shown to affect the activity of natural killer (NK) cells and CD8T cells. However, a comprehensive biological analysis and exploration of NKG2A in different cancers is lacking and this needs to be further investigated. Metho...
正如预期的那样,细胞毒性细胞特征主要表达在CD8+ T细胞或自然杀伤(NK)细胞中,而与细胞外基质形成相关的Fges主要富集在成纤维细胞中。最终的Fges具有高度的细胞类型特异性,与每个签名相关的细胞类型的表达得分较高,而非靶细胞群体的表达得分较低(Mann-Whitney p值< 10?100)(图S1B),显示了4,212个细胞图谱的有效分...
protein-binding activity modulator, extracellular matrix protein or intercellular signaling molecule. Concordance of these biomarkers with validated molecular signatures of cachexia and senescence supported relevance to muscle and cachexia disease biology, and high tumor expression of the biomarker set associated...
(Fig.1e). The myeloid cells were further divided into monocytes, macrophages and dendritic cells (Fig.1e). The CD8 + T cells, CD4 + T cells, regulatory T cells (Treg cells) and natural killer cells (NK cells) were identified from the T&NK cluster (Fig.1e). Similarly, ...
Importantly, the references for annotation encompassed expected cell types within the tumour microenvironment (TME), which include, but are not limited to, B cells, dendritic cells, endothelial cells, epithelial cells, fibroblasts, macrophages, monocytes, NK cells, platelets, smooth muscle cells, and...
[62] and tumors with high LM.SIG score earned decreased infiltration of anti-tumor immune cells, including NK cells and cytotoxic lymphocytes (Fig.3B). Then, we calculated the correlation analysis between GSVA scores of the hallmark gene set and LM.SIG to dig into whether immunosuppressive ...
(Fig.1e). The myeloid cells were further divided into monocytes, macrophages and dendritic cells (Fig.1e). The CD8 + T cells, CD4 + T cells, regulatory T cells (Treg cells) and natural killer cells (NK cells) were identified from the T&NK cluster (Fig.1e). Similarly, ...
1). We found that this structure yields stronger performance as compared to only having CD8+ cells in one of the branches or generating a single model to differentiate between CD4+, CD8+ and NK all at once. Overall, given that a small random data subset was utilised to infer transcriptomic...
Cancer cells employ various mechanisms to evade immune surveillance and avoid elimination by tumor-suppressing immune cells, which include NK cells, M1-polarized macrophages, and effector T cells5. Cancer immunotherapy, particularly the use of immune checkpoint inhibitors (ICIs) therapy, aimed at ...