Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mappingdoi:10.1038/s41590-024-01884-zThe functional diversity of natural killer (NK) cell repertoires stems from differentiation, homeostatic, receptor鈥搇igand interactions and adaptive-like responses to viral...
ConclusionsHyperoside could promote the proliferation of NK cells at certain concentrations and maybe enhance the killing effect against pancreatic cancer PANC1 cells through up-regulating the expression of perforin and granzyme B in NK cells. KEYWORDS: Pancreatic neoplasms;Hyperoside;Killer cells, natural...
Small cell lung cancer COAD: Colon adenocarcinoma HNSC: Head-neck squamous cell carcinoma TAMs: Tumor-associated macrophages PRAD: Prostate adenocarcinoma scRNA-seq: Single-cell RNA sequencing NK: Natural killer pDCs: Plasmacytoid dendritic cells mIHC: Multiple immunofluorescence PR: Partial...
Large-scale, pan-cancer analysis is enabled by data driven knowledge bases that link tumor molecular profiles with phenotypes. A debilitating cancer-related phenotype is skeletal muscle loss, or cachexia, which occurs partly from tumor products secreted into circulation. Using the LinkedOmicsKB knowledge...
In recent years, the analysis of tumorigenesis and progression in pan-cancer has been increasingly studied. Pan-carcinoma analysis allows the analysis of genes in multiple cancers, in which differences and similarities in the expression of extracted genes are compared5, revealing similarities and differ...
Metastasis remains a leading cause of cancer-related mortality, irrespective of the primary tumour origin. However, the core gene regulatory program governing distinct stages of metastasis across cancers remains poorly understood. We investigate this thr
Cancer cells employ various mechanisms to evade immune surveillance and avoid elimination by tumor-suppressing immune cells, which include NK cells, M1-polarized macrophages, and effector T cells5. Cancer immunotherapy, particularly the use of immune checkpoint inhibitors (ICIs) therapy, aimed at ...
macrophages and dendritic cells (Fig.1e). The CD8 + T cells, CD4 + T cells, regulatory T cells (Treg cells) and natural killer cells (NK cells) were identified from the T&NK cluster (Fig.1e). Similarly, cells from the other 5 types of cancer were clustered into roughly th...
胰腺肿瘤金丝桃苷杀伤细胞,天然细胞系,肿瘤细胞增殖目的 观察金丝桃苷对人NK细胞体外增殖及杀伤胰腺癌PANC1细胞活性的影响,探讨其可能机制.方法 分离健康人外周血单个核细胞(PBMCs),应用含IL-2的NK细胞培养液加不同浓度(0.3,1.6,8,40,200 μg/ml)的金丝桃苷溶液诱导PBMCs 12 d,以不加金丝桃苷作为对照...
论文理解Conserved pan-cancer microenvironment subtypes predict response to immunotherapy T大泽哥 清华大学研究生 3 人赞同了该文章 注:conserved (生物):在不同的……中保持不变,这里表示在不同的泛癌中保持不变,翻译为:保守的 总结 作者通过无监督的方式划分了四个免疫微环境亚型,整合了转录组数据和基因组...