译文标题:基于RNA适配体的PROTAC选择性降解p53-R175H致癌热点突变体 原文摘要: TP53encodes the tumour suppressor protein p53, a master regulator of genomic integrity and cell survival, and is the most frequently mutated gene.1p53 mutant proteins are stabilised and can acquire dominant-negative or oncog...
Despite the potential of PROTACs, limited research has been directed toward the degradation of the p53-R175H mutant protein. In this study, we developed a series of peptide-based PROTACs, leveraging known peptide ligands for both the p53-R175H mutation and the E3 ubiquitin ligase VHL. Our ...
产品规格 目录价 数量 93012ES25 25μg 1485.00 93012ES60 100μg 5065.00 93012ES76 500μg 16875.00 批量采购,请点击询价 下载产品说明书 产品说明书 FAQ COA 已发表文献 性能参数 表达区间及表达系统(Source) Recombinant Biotinylated Human P53 R175H (HLA-A*02:01) Protein is expressed from HEK293 wit...
PE-labeled Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC93055ES 价格电议 起批量≥1 盒 最小起订1盒 供货总量电询 发货地址上海市浦东新区 建议售价￥15565.00/盒 更新日期2025年02月24日 产品规格100μg 即时洽谈立即询价查看联系方式 收藏产品发送留言 ...
Gain-of-function p53 mutants such as p53-R175H form stable aggregates that accumulate in cells and play important roles in cancer progression. Selective degradation of gain-of-function p53 mutants has emerged as a highly attractive therapeutic strategy t
活性(Activity) SPR Data: Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer, His Tag captured on CM5 Chip via Anti-His Antibody can bind Anti-HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Antibody, hFc Tag with an affinity constant of 2.35 nM as determined in SPR assay . ...
本发明提供了吡啶硫酮锌在制备预防和/或治疗p53R175H突变癌症的药物中的应用。本发明通过高通量药筛发现Zinc Pyrithione能够显著抑制携带p53R175H突变的细胞系,并能够通过抑制p53R175H突变的下游基因METTL3及FOXA2的蛋白水平发挥抑癌作用,并在体内外实验中给与证明。 二、法律状态 法律状态公告日法律状态法律状态信息...
CELLULAR TUMOR ANTIGEN P53 (R175H),来源于药化词典-药智数据
Despite the potential of PROTACs, limited research has been directed toward the degradation of the p53-R175H mutant protein. In this study, we developed a series of peptide-based PROTACs, leveraging known peptide ligands for both the p53-R175H mutation and the E3 ubiquitin ligase VHL. Our ...
hTERT-immortalized prostate epithelial EP156T cells retained intact wt-p53 activity.9 The p53R175H mutation is commonly found in cancer cells including prostate cancer,10 and it is known to confer an oncogenic GOF activity on a background of wt-p53.4 To investigate the effect of p53 mutation...