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the p53 pathway operates on 'standby' mode. Activation occurs in response to a variety of cellular stresses such as DNA damage and expression of activated oncogenes. See [1] for a more detailed description of the pathways activated by specific stresses. Post-translational modifications (such as...
The tumor suppressor geneTP53is the most frequently mutated gene in human tumors.1,2The process of tumor development is strongly related to the dysfunctions caused byTP53mutations.3,4p53 protein functions primarily as a transcription factor, which regulates a wide variety of pathways, such as cell...
Up-regulation of LINC01010 and lncRNA CASC15 can regulate the p53 signaling pathway and apoptosis process by regulation of PERP expression level as a breas... M Karimi,ZF Novin,A Naghieh,... 被引量: 0发表: 2022年 The ARF/p53 pathway The ARF tumor suppressor connects pathways regulated ...
Of all the tumor suppressor gene pathways that play a role in tumor development, few are as important as the p53 pathway. Commonly regarded as the most fre... ME Murphy - 《Cell Death & Differentiation》 被引量: 0发表: 2006年 Two Polymorphic Variants of Wild-Type p53 Differ Biochemically...
[5] Rozenblum E, Schutte M, Goggins M, et al. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res. 1997;57(9):1731-1734.[6] Notta F, Chan-Seng-Yue M, Lemire M, et al. A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns [published correction...
Modeling crosstalk between the HIF-1 and p53 pathways. We constructed an integrated model to explore the cell-fate decision upon hypoxia, characterizing the activation of HIF-1α and p53, their selective expression of target genes and apoptosis induction (Fig. 1). We focused on the interplay be...
[4] Wang H, Guo M, Wei H, Chen Y. Targeting p53 pathways: mechanisms, structures, and advances in therapy. Signal Transduct Target Ther. 2023, 1;8(1):92. [5] Li B, Cheng Q, Li Z, et al. p53 inactivation by MDM2...