signaling pathway and howTP53mutations impact tumor progression. We also discuss key structural features of the p53 protein and its inactivation by oncogenic mutations. In addition, we review the efforts that have been made in p53-targeted therapies, and discuss the challenges that have been encount...
signaling pathway and howTP53mutations impact tumor progression. We also discuss key structural features of the p53 protein and its inactivation by oncogenic mutations. In addition, we review the efforts that have been made in p53-targeted therapies, and discuss the challenges that have been encount...
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Searching for small-molecules that activate the transcriptional activity of p53 would be expected to lead to the discovery of both DNA-damaging agents and compounds that are specific for the p53 pathway, including agents that interact directly with p53 (Issaeva et al., 2004) or that inhibit ...
Martins et al. (2006) also demonstrate that restoration of p53 activity results in tumor regression but add the sobering caveat that tumors may be able to quickly generate resistance by finding other ways to disrupt the p53 pathway. 展开 ...
However, disruption of the p53 pathway can occur through mechanisms other than TP53 mutation, and we have recently developed a simple screening test that detects p53 dysfunction due to mutation of the genes encoding either p53 or ATM, a kinase that regulates p53. The present study was conducted...
p53-dependent induction of SAT1 – a protein that functions in the polyamine pathway and promotes lipid peroxidation – also contributes the ferroptotic response [29]. The ability to promote apoptosis and ferroptosis are separable functions of p53 and, strikingly, the ability to promote ferroptosis...
Using Ingenuity Pathway Analysis, we found that 43 out of the 192 mapped genes are early p53 target genes significantly associated with func- tions related to cellular movement (Table 2). In keeping with this notion, we noted that wild-type and p53 -/- HCT116 cells responded differently to...
As expected, the p53 signaling pathway (P ¼ 8.6 Â 10 À 8), and pathways related to the control of the cell cycle (P ¼ 1.3 Â 10 À 3), is among the most significant semantic terms. Moreover, an over-representation of genes encoding for enzymes in the metabolism of ...