简单的说，就是TP53和TRP53是基因的叫法，分别是human 和mice的，而他们表达的蛋白叫P53。p53是一种肿瘤抑制基因。该基因编码一种分子量为53kDa的蛋白质，命名为P53。p53基因的失活对肿瘤形成起重要作用。但是事物必然有它的两个方面，p53是一个重要的抗癌基因使癌细胞凋亡，从而防止癌变；还具有帮助细...
[2] The first 30 years of p53: growing ever more complex [3] Insights into wild-type and mutant p53 functions provided by genetically engineered mice [4] A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies [5]The gut microbiome switches mutant p53 from...
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P53 null mice: damaging the hypothesis? 来自 Semantic Scholar 喜欢 0 阅读量: 30 作者:OJ Sansom,AR Clarke 摘要: P53 is extremely well characterised as a tumour suppressor gene, and many activities have been attributed to it which are consistent with this function. However, despite being the ...
21.Johnson, Leisa , et al. "Somatic activation of the K-ras oncogene causes early onset lung cancer in mice." Nature 410.6832(2001):1111-1116.
Understanding the p53 tumor suppressor pathway remains crucial for the design of anticancer strategies. Studies in human tumors and mouse models help to unravel the molecular mechanisms that underlie the p53 signaling pathway. Yet, the p53 gene regulatory network (GRN) is not the same in mice and...
p53 is an important inducer of organismal aging. However, its roles in the aging of skin remain unclear. Here we show that mice with chronic activation of p53 develop an aging phenotype in the skin associated with a reduction of subcutaneous fat and loss
1. Jones SN, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995;378(6553):206-8 doi 10.1038/378206a0.2. Karni-Schmidt O, Lokshin M, Prives C. The Roles of MDM2 and MDMX in Cancer. Annu Rev Pathol 2016;11:617-...
3. S. Park et al., Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice. Nat. Cell Biol. 19, 155–163 (2017). doi: 10.1038/ncb3472; pmid: 28248302 4. M. Aragona et al., Defining stem cell dynamics and migration during wound healing in mouse ...
Ionizing radiation also seems to strongly promote medulloblastoma development in PTCH heterozygotes when applied to newborn mice in which the EGL is still proliferating.51 In all of these models, tumors developed months after the initial genetic insults, suggesting additional mutational events were ...