简单的说，就是TP53和TRP53是基因的叫法，分别是human 和mice的，而他们表达的蛋白叫P53。p53是一种肿瘤抑制基因。该基因编码一种分子量为53kDa的蛋白质，命名为P53。p53基因的失活对肿瘤形成起重要作用。但是事物必然有它的两个方面，p53是一个重要的抗癌基因使癌细胞凋亡，从而防止癌变；还具有帮助细胞
[2] The first 30 years of p53: growing ever more complex [3] Insights into wild-type and mutant p53 functions provided by genetically engineered mice [4] A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies [5]The gut microbiome switches mutant p53 from...
When mouse models are employed for the study of p53, it is important to know what biological processes are commonly regulated by p53 and what biological pathways diverged in their p53 response during evolution. Genes commonly up-regulated by p53 in mice and humans are enriched for GO terms asso...
Ionizing radiation also seems to strongly promote medulloblastoma development in PTCH heterozygotes when applied to newborn mice in which the EGL is still proliferating.51 In all of these models, tumors developed months after the initial genetic insults, suggesting additional mutational events were ...
p53 is an important inducer of organismal aging. However, its roles in the aging of skin remain unclear. Here we show that mice with chronic activation of p53 develop an aging phenotype in the skin associated with a reduction of subcutaneous fat and loss
Meth A fibrosarcoma cells express two transforming mutant p53 species. Oncogene, 3.3 (1988):313-21 21.Johnson, Leisa , et al. "Somatic activation of the K-ras oncogene causes early onset lung cancer in mice." Nature 410.6832(2001):1111-1116....
35、t al. Super p53 mice exhibit enhanced DNA damage response, are tumor resistant and age normallyJ. The EMBO journal, 2002, 21(22): 6225-6235.17. Matheu A, Maraver A, Klatt P, et al. Delayed ageing through damage protection by the Arf/p53 pathwayJ. Nature, 2007, 448(7151): 375...
A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice. Oncogene 2006; 25:1277-1280.WANG Y,ZHANG Z,LUBET R A. A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice[J].Oncogene,2006,(08):1277-1280.doi:10.1038/sj.onc.1209182....
1. Jones SN, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995;378(6553):206-8 doi 10.1038/378206a0.2. Karni-Schmidt O, Lokshin M, Prives C. The Roles of MDM2 and MDMX in Cancer. Annu Rev Pathol 2016;11:617-...
Mice which partially lack the manganese superoxide dismutase (MnSOD) gene, an enzyme that catalyzes the partitioning of the superoxide radical into molecular oxygen or hydrogen peroxide, have increased liver injury post-APAP, highlighting the importance of mitochondrial oxidant stress in the progress...