Mechanistically, AKI was associated with the upregulation of several known p53 target genes, including Bax and p21, and this association was attenuated in p53-KO mice. Furthermore, the expression of miR-192-5p was significantly decreased in the p53-KO kidney tissues. In human renal tubular ...
To evaluate if acute p53 ablation in established obesity can rescue the inflammatory phenotype of AT, we analysed the expression of inflammatory markers in control and p53 KO mice before challenging them with IF (efficiency and specificity of ablation is shown in Supplementary Fig. 3d). The ...
Furthermore, photic entrainment of p53 KO mice is unusual under lightdark conditions. These findings suggest that p53 is involved in entrainment of the circadian behavioral rhythm.doi:10.1111/gtc.12144Toshiyuki HamadaApplied Molecular-Imaging Physics, Hokkaido University Graduate School of Medicine, ...
Featured Product KD/KO验证 P53 Monoclonal antibody P53 Monoclonal Antibody for WB, IHC, IF/ICC, ELISA Cat No. 60283-2-Ig CloneNo. 6C4B6 引用文献(274) 宿主/亚型 Mouse / IgG2b 种属反应性 human, rat and More (4) 应用 WB, IHC, IF/ICC, ELISA and More (3) 别名 TP53, Tumour...
Numerous GEMMs have been developed to study SCLC, with almost all of them containing conditional alleles ofRb1(floxed exon 19) andp53(floxed exons 2–10). In these mice aggressive neuroendocrine lung tumours can be induced upon intra-nasal or intra-tracheal delivery of Adeno-Cre viruses [145]...
The relationship between p53 expression and neuronal cell death has been evaluated in numerous models of injury and disease (Table 2). p53-deficient mice or neurons derived from these mice have been used most often, but inhibitors of p53 expression or p53 function have also been used to evaluat...
原名:Knockout of ASPP2 promotes DEN-inducedhepatocarcinogenesis via the NF-κB pathway in mice 译名:ASPP2基因敲除通过NF-κB途径促进DEN诱发小鼠肝癌的发生 期刊:Cancer Gene Therapy IF:5.987 发表时间:2021.02 通讯作者:陈德喜,刘...
3.Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, Chernov MV, Gudkov AV. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.Science. 1999;285:1733-1737.[PubMed][DOI] 4.Grossmann J, Walther K, Artinger M, Kiessling S, Steinka...
构建p53 凋亡刺激蛋白 2(ASPP2)基因敲除小鼠,用该小鼠建立二乙基亚硝胺(DEN)诱导的肝癌模型以研究 ASPP2 的生物学功能。 方法 构建单链向导 RNA 寡聚核苷酸,用 CRISPR/Cas9 系统制备 ASPP2 基因敲除小鼠。采用 PCR 法和测序方法鉴定 F...
The depletion of senescent cells in aging mice delayed age-related morbidity and decreased the incidence of tumorigenesis and cancer-related death [33]. This is thought to be due to the removal of the SASP that may promote tumorigenesis by inducing chronic inflammation, a known driver of ...