英文名称: p53 knockout mice 总访问: 6966 国产/进口: 国产 半年访问: 90 产地/品牌: 北京百奥赛图基因生物技术有限公司 产品类别: 实验动物 规格: BCG‐DIS-0001 最后更新: 2024-6-24 货号: 参考报价: 详谈请电01056315318 立即询价 电话咨询 ...
Mice, Mutant StrainsNeoplasms, ExperimentalGenetic Predisposition to DiseaseTumor Suppressor Protein p53Mutations in the p53 tumour-suppressor gene are the most frequently observed genetic lesions in human cancers. To investigate the role of the p53 gene in mammalian development and tumorigenesis, a null...
转基因或基因敲除小鼠行为学表型鉴定手册 What's Wrong With My Mouse?--Behavioral Phenotyping of Transgenic and Knockout Mice (Second Edition) 热度: 第29卷 第1期 2012年2月 实验动物科学 LAB0RATORYANIMALSCIENCE V01.29 No.1 February2012 p53基因敲除小鼠的饲养繁殖及鉴定 ...
Mohd. Nazil Salleh., Patimah Ismail., Yun Hin Taufiq-Yap., Paul Carmichael.. (2004) Identification of Estrogen-responsive Genes in p53+/- Knockout and Isogenic Wild-type Parent Strain Mice by CDNA Macroarray Analysis. Journal of Medical Sciences(Faisalabad) 4 , 312-317 /...
Consistent with this, p53-knockout mice are highly prone to the spontaneous development of different tumours7,8. However, ~70% of spontaneous tumours arising in p53-deficient mice are lymphomas9,10, with the underlying mechanisms unknown. The activation of p53 is able to induce a range of ...
[60]. p53 knockout mice demonstrate that p53 is critical for preventing tumorigenesis. For instance, p53 knockout mice are sensitive to carcinogens such as dimethylnitrosamine induced tumors [61]. Furthermore, in the context of 129/sv and C57BL/C, p53-/- mice develop tumors earlier than ...
Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta micedoi:10.1016/j.tox.2012.12.005ApoptosisKaryomegalyMutagenicityp53OchratoxinAOchratoxin A (OTA) is a mycotoxin produced by fungal species and is carcinogenic targeting the \\{S3\\} segment of the renal ...
Ohmi K, Shinoura H, Nakayama Y, Goda N, Tsujimoto G. Character- ization of a1-adrenoceptors expressed in a novel vascular smooth muscle cell line cloned from p53 knockout mice, P53LMAC01 (AC01) cells. Br J Pharmacol 1999;127:756-62....
Inducible GPX4 knockout mice lose body weight and die within 2 weeks, while global knockout mice die within 48 h of birth (Yoo et al., 2012). Transgenic overexpression of human GPX4 in mice greatly reduced buthylhydroperoxide and diquant-induced liver damage and lipid peroxidation as well...
(1)Animal experiments:the wild—type mice and p53 knockout mice were divided into four group:wild--type sham group;wild-・ type operation group;p53 knock out sham group;p53 knock out operation group. (2)Cell experiments:siRNA negative control group;siRNA p53 group;siRNA negative control+...