p53可驱动MCL-1降解,从而克服了对venetoclax耐药的主要机制,而BCL-2抑制剂促进了p53驱动的细胞凋亡。 罗氏和艾伯维正在合作测试这种组合,Andreeff是研究人员之一。初步的I/II期结果显示,缓解率为40%–50%。这项试验正在进行中。 随着对p53理解的不断发展,其他策略也在兴起。由于p53在肿瘤免疫中的作用(癌细胞可通过p...
PIAS1介导P53的SUMO化通过P53-Bax信号通路调控晶状体上皮细胞凋亡 热度: 云芝糖肽(PSP)诱导白血病细胞凋亡中死亡受体信号调控途径的研究 热度: zinc induces apoptosis on cervical carcinoma cells by p53-dependent and -independent pathway.锌对宫颈癌细胞凋亡p53-dependent和独立的途径 ...
MDM2抑制剂活化了p53,p53促进了MCL-1的降解,从而克服了对venetoclax的耐药。反过来,抑制BCL-2也促进了p53驱动的细胞凋亡。罗氏和艾伯维正在合作推进该组合的临床研究。 日本第一三共公司(Daiichi Sankyo)正在测试MDM2抑制剂milademetan与新一代FLT3抑制剂quizartinib。诺华公司也在做类似的事情。 随着人们对p53的理解逐渐...
观察弥漫大B细胞淋巴瘤(DLBCL)组织中髓样细胞白血病基因1(MCL一1)及其相关因子信号转 导和转录激活因子(STAT3)和p53的表达变化,并探讨其临床意义。方法 应用免疫组化法检测75例DLBCL组 织(DLBCL组)、20例反应性淋巴增生组织(对照组)中的MCL一1、STAT3、p53,分析各指标与DLBCL临床病理参数 ...
肿瘤发生中起着重要的作用.p53的诱导凋亡作用对抑制肿瘤发生至关重要,其能激活多种凋亡相关基因的表达,但其决定性作用的机制尚不明确.p53上调凋亡调控因子(PUMA)与髓细胞白血病基因1(MCL-1)作为p53的靶分子,在决定细胞是否凋亡的过程中起重要作用.该文对细胞凋亡过程中p53基因的激活及其对下游PUMA、MCL-1作用的...
In patients with T3 gastric carcinoma who underwent curative surgery; however, Mcl-1()/p53 () tumor demonstrated the best postoperative survival rate, whereas Mcl-1(+)/p53(+) tumor had the worst. Conclusion The expression of Mcl-1 is an indicator of tumor progression and postoperative ...
These results indicate that besides TS, also Rb, p53 and mcl-1 are correlated with clinical outcome in patients with liver metastases from colorectal cancer. 展开 关键词: Rubidium Genes, p53 Expression, NOS Clinical Secondary malignant neoplasm of liver, NOS 铷 基因, P53 三尖瓣狭窄 蛋白质类...
Use of MCL-1 (myeloid cell leukemia-1) as a biomarker and target for cancer prognosis and treatment has more publications than the publications from the use of XIAP as a biomarker and target in the cancer field. For example, in terms of MCL-1 as a prognostic biomarker, analysis of Bcl-...
Furthermore, PUMA chemosensitized intrinsically resistant SKOV3 cells to cisplatin through downregulation of B-cell lymphoma-extra large (Bcl-xL) and myeloid cell leukemia sequence 1 (Mcl-1). PUMA-mediated Bcl-xL downregulation mainly happened at the transcription level, whereas PUMA-induced Mcl-1 ...
On the other hand, Bax mediated release of the cytochrome C is repressed by Bcl-2 protein family (Bcl-2, Bcl-XL, Mcl-1, Bcl-w, A1, Bcl-L10, Bcl-G and Bcl-Rambo) whereas, so called BH3-only family of proteins (such as Puma, Noxa, Bad, Bid, Bim, Hrk, Bik and Bmf) bind ...