Hemann MT, Lowe SW (2006) The p53-Bcl-2 connection. Cell Death Differ 13: 1256-1259.HEMANN, M.T. and LOWE, S.W. (2006). The p53-Bcl-2 connection. Cell Death Differ 13: 1256-9.Hemann, M. T. and S. W. Lowe. The p53-Bcl-2 connection. Cell Death Differ 13: 1256 – 1259...
The first mechanistic connection between p53 and Bcl-2 came from the identification of the proapoptotic ‘multi-domain’ Bcl-2 family member Bax, initially identified by the Korsmeyer laboratory.25 p53 directly induces Bax transcription.26 Additionally, Bax induction by stress-activated p53 can overco...
Therefore, phosphorylation prevents cleavage of the key caspase-2 substrates involved in apoptosis and p53 stabilization (see below). Caspase-2 – cell cycle connection Possible links between caspase-2, p53 and the cell cycle have been consistently reported. For example, caspase-2-deficient murine ...
Clinical and Experimental Gastroenterology Open Access Full Text Article The p53/microRNA connection in gastrointestinal cancer Dovepress open access to scientific and medical research Review Matjaz Rokavec Huihui Li Longchang Jiang Heiko Hermeking Experimental and Molecular Pathology, Institute of Pathology...
Anti-inflammatory Death receptor, mitochondria and endoplasmic reticulum pathway, caspase, p53, Bcl-2 Caspases, Bcl-2, Bax, p53, Fas Necroptosis Activation of kinases and drop in ATP levels Plasma membrane rupture, organelleswelling, moderate chromatin condensation Pro-inflammatory TNF-α, TNFR1, TLR...
The cGAS–STING pathway is primarily activated by dsDNA that enters the cytoplasm abnormally; therefore, it is tempting to emphasize the connection between the cGAS–STING pathway and viral infections, such as those caused by classical herpes simplex virus type 1 [71]. Considerable research results...
Exploring the p53 connection of cervical cancer pathogenesis involving north-east Indian patients Background As per WHO, Cervical cancer (CaCx) is a global issue, being the fourth common cancer in women with incidence rate of 13.1 per 1 lakh women globa... MA Khan,D Tiwari,A Dongre,... -...
Bax and Bad are pro-apoptotic proteins, while Bcl-2 and Bcl-x are anti-apoptotic proteins [74]. Bax permeabilizes the mitochondrial outer membrane, releasing pro-apoptotic factors that activate caspases [75], which can then active the nuclear protein PARP [76]. While Bcl-2 can bind to ...
This well-designed study identifies a specific brain–spleen neural connection in mice that enhances humoral responses in response to an elevated platform regimen. Article CAS PubMed Google Scholar Rosas-Ballina, M. et al. Splenic nerve is required for cholinergic antiinflammatory pathway control of...
R. The PI3K–PDK1 connection: more than just a road to PKB. Biochem. J. 346, 561–576 (2000). Article CAS PubMed PubMed Central Google Scholar Stokoe, D. et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 277, 567–570 (...