Microtubule-associated protein tau (MAPT) in the lens of the eye in non-transgenic and transgenic tau mutant (P301S) miceBackground We previously discovered that A尾 accumulates in the cortical/supranuclear region of the lens in people with Alzheimer's Disease (AD) (Goldstein...
Jax资料：jaxmice.jax.org/strain/008169.html Alzforum资料：www.alzforum.org/research-models/tau-p301s-line-ps19 Goodwin LO, et al. Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis.bioRχiv preprint first posted online Dec. ...
通过hAPOE4(NM-HU-190002)与hMAPT-P301S(NM-KI-233262)小鼠交配获得。 *使用本品系发表的文献需注明: Mapt-hMAPT-P301S/hAPOE4 mice (Cat. NO. NM-XA-240812) were purchased from Shanghai Model Organisms Center, Inc.. 你也可能感兴趣
P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS One. 2011;6(6):e21050. Yoshiyama Y, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 2007 Feb 1;53...
Takeuchi H, et al. P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS One. 2011;6(6):e21050. Yoshiyama Y, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neu...
Starting from the age of 2-3 months the mice showed marked hyperactivity, abnormal placing of weight on the hindlimbs and defective nest building in their home cage. These behavioral impairments did not progress with age. In addition, there was a progressive development of hindlimb clasping, ...
Studies on P301S mice aiming to distinguish more clearly between the impact of tau and amyloid have revealed the occurrence of an RGC axonopathy associ- ated with reactive microgliosis and vasculopathy [18, 65]. Xia et al. [65] recently showed that p-tau was distributed throughout the...
Takeuchi H, et al. P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS One. 2011;6(6):e21050. Yoshiyama Y, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neu...
In vivo long term imaging of FSB-positive cells displays the disease progression in P301S mice.Christian SchönNadine A. HoffmannSimon M. OchsSteffen BurgoldSeverin FilserSonja SteinbachMathias W. SeeligerThomas ArzbergerMichel GoedertHans A. Kretzschmar...
We inoculated OHCs prepared from P301S mouse pups with brain homogenate from terminally ill P301S mice and then examined the slices for viability and the production and localization of insoluble phosphorylated tau. We show that following seeding, phosphorylated insoluble tau accumulate in a time and...