MAIT细胞在P301S人源tau转基因小鼠神经炎症中的调节作用 《Journal of Neuroinflammation》:MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic mice 在神经退行性疾病领域,tau蛋白异常聚集引发的神经炎症和神经退行性一直是研究热点。近期,一项发表于《Journal of Neuroinflammation》的研究深...
MAIT细胞在P301S人源tau转基因小鼠神经炎症中的调节作用 《Journal of Neuroinflammation》:MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic mice 在神经退行性疾病领域,tau蛋白异常聚集引发的神经炎症和神经退行性一直是研究热点。近期,一项发表于《Journal of Neuroinflammation》的研究深...
Microtubule-associated protein tau (MAPT) in the lens of the eye in non-transgenic and transgenic tau mutant (P301S) miceBackground We previously discovered that A尾 accumulates in the cortical/supranuclear region of the lens in people with Alzheimer's Disease (AD) (Goldstein...
Jax资料：jaxmice.jax.org/strain/008169.html Alzforum资料：www.alzforum.org/research-models/tau-p301s-line-ps19 Goodwin LO, et al. Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis.bioRχiv preprint first posted online Dec. ...
P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS One. 2011;6(6):e21050. Yoshiyama Y, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 2007 Feb 1;53...
Starting from the age of 2-3 months the mice showed marked hyperactivity, abnormal placing of weight on the hindlimbs and defective nest building in their home cage. These behavioral impairments did not progress with age. In addition, there was a progressive development of hindlimb clasping, ...
Takeuchi H, et al. P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS One. 2011;6(6):e21050. Yoshiyama Y, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neu...
Studies on P301S mice aiming to distinguish more clearly between the impact of tau and amyloid have revealed the occurrence of an RGC axonopathy associ- ated with reactive microgliosis and vasculopathy [18, 65]. Xia et al. [65] recently showed that p-tau was distributed throughout the...
Takeuchi H, et al. P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS One. 2011;6(6):e21050. Yoshiyama Y, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neu...
All mouse experiments were approved by the Committee on Animal Care of the Division of Comparative Medicine at Massachusetts Institute of Technology (MIT). Two-month-old male tau P301S mice and respective wild type (WT) control mice were used. For tissue dissection, mice were chosen in an al...