Gasparini L., Anthony Crowther R., Martin K.R., Berg N., Coleman M., Goedert M., Spillantini M.G. Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice. Effects on axo- nal viability. Neurobiology Aging, 32: 419-433, 2009....
P301S小鼠中,MAIT细胞缺失导致脑膜屏障完整性受损,进而引发微胶质细胞炎症反应增强和tau病理加剧。通过MAIT细胞过继转移实验,研究人员证实了MAIT细胞能够恢复脑膜屏障完整性,并抑制微胶质细胞炎症反应,从而减轻tau病理和海马萎缩。 在研究结果部分,研究人员通过流式细胞术分析发现P301S小鼠脑膜中MAIT细胞数量增加,并且这些细...
Takeuchi H, et al. P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS One. 2011;6(6):e21050.Yoshiyama Y, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. ...
P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS One. 2011;6(6):e21050. Yoshiyama Y, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 2007 Feb 1;53...
P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS One. 2011;6(6):e21050. Yoshiyama Y, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 2007 Feb 1;53...
Takeuchi H, et al. P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. PLoS One. 2011;6(6):e21050. Yoshiyama Y, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neu...
Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice. FASEB J. 2011; 25 :4063–4072.Dumont M, Stack C, Elipenahli C, Jainuddin S, Gerges M, Starkova NN, et al. Behavioral deficit, oxidative stress, and mitochondrial dysfunction ...
We have recently demonstrated that P301S mutant human tau (tau P301S ) mice develop tau filamentous inclusions and axonopathy in retinal ganglion neurons (RGCs), in the absence of neuronal loss or alterations in the outer retina. Moreover, we showed that tau P301S transgenic retinal ...
While mice transgenic for full-length P301S Tau had a heavy load of sarkosyl-insoluble Tau in spinal cord at 16 months of age and suffered from a severe paraparesis, the deletion lines did not develop significant levels of sarkosyl-insoluble Tau and had a normal lifespan. In addition, ...
years.And transgenic animal models based on tau mutations have been established.Among these models,P301 S transgenic mouse has been widely used in the research on tauopathies.This article reviews the research progress in pathogenic manifestations of P301S mutant tau transgenic mice and ...