P2Y12 inhibitor monotherapy or dual antiplatelet therapy after coronary revascularisation: individual patient level meta-analysis of randomised controlled trials https://pubmed.ncbi.nlm.nih.gov/34135011/
haveshownthatthelevelofplateletinhibitionbyclopi- dogrelvariesconsiderablybetweenpatients(6,7).Platelet(最高达50%,取决于检测方法患者存在治疗中高 functionmeasurementsindlopidogrel-treatedpatientshave shownthat,onaverage,25%6ofpatiente(upto50%,de-血小板反应性(HTRP) ...
(Suzuki et al., 2019). P2Y12 signaling elevates the intracellular level of Ca2+through the activation of NFAT and induces the release of CCL3 chemokines in primary microglia (Tozaki-Saitoh et al., 2017). P2Y12 receptor was found to be upregulated in response to IL4-mediated anti-...
Here, we show that the level of P2Y(12)R mRNA expression was markedly increased in the spinal cord ipsilateral to the nerve injury and that this expression was highly restricted to ionized binding calcium adapter molecule 1-positive microglia. An increase in the immunofluorescence of P2Y(12)R ...
2017年欧洲心脏病学会成人心脏手术患者血液管理指南建议对出血患者进行抗纤溶治疗(class I,level A);围术期,对出血患者根据床旁即时检测制定治疗方案,可减少输血次数(class IIa,level B)。然而,本指南并未明确在采用粘弹性分析如TEG或Rotem时,启动干预治疗时的临界值。此外,两项Meta分析中纳入的随机对照试验和观察性...
Supplementary Information Additional file 1: Fig. S1. a The picture of injection site. b The picture of infection area. c The P2Y12 level of mRNA in mPFC. Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits ...
were also detected in human-derived megakaryocyte cell strains (Meg-01) treated with different concentration of adenosine diphosphate (ADP). CFTRinh-172, a selective CFTR chloride channel blocker was also applied to observe how ...
[10]Elmariah S,Doros G,Benavente O,et al.Impact of clopidogrel therapy on mortality and cancer in patients with cardiovascular and cerebrovascular disease:a patient-level meta-analysis[J].Circ Cardiovasc Interv,2018,11(1):005795.[11]Serebruany V,Kim M,Cabrera-Fuentes H,et al.Mortality and ...
(Co-Chair, interdisciplinary curriculum), Level Ex, Medtelligence/ReachMD (CME steering committees), MJH Life Sciences, Piper Sandler, Population Health Research Institute (for the COMPASS operations committee, publications committee, steering committee, and USA national co-leader, funded by Bayer), ...
Level Ex, Medscape Cardiology, MyoKardia, NirvaMed, Novo Nordisk, PhaseBio, PLx Pharma, Regado Biosciences, Stasys; Board of Directors: Boston VA Research Institute, DRS.LINQ (stock options), Society of Cardiovascular Patient Care, TobeSoft; Chair: Inaugural Chair, AHA Quality Oversight Committee;...