platelet functions, and interindividual variability. Hence, advanced studies have been carried out to achieve more efficient and safer P2Y12blockade. In this review, we provide a brief but comprehensive report on P2Y12, its role on platelet thrombus formation, and the targeting of this receptor as...
12) compared with nonsense siRNA control (siNC), and (E) western blot and (F) real-time PCR show that silencing P2Y12 greatly blocks TGF-β1 (5 ng/mL)-induced Smad3 phosphorylation (p-Smad3), expression of P2Y12, TGF-β1, α-SMA, and collagen I at mRNA and/or protein levels. ...
Exposure of mice to the P2Y14 ligand, UDP-glucose increased IL-33 expression, as well as eosinophil and lymphocyte recruitment in the lungs to levels on par with mice exposed to various allergens (HDM, cockroach allergen, or alternaria species) [53]. Early in vivo evidence has suggested P2Y...
platelet functions, and interindividual variability. Hence, advanced studies have been carried out to achieve more efficient and safer P2Y12blockade. In this review, we provide a brief but comprehensive report on P2Y12, its role on platelet thrombus formation, and the targeting of this receptor as...
Inhibition of the P2Y12 receptor is a well-established strategy for anti-thrombotic therapy; Plavix®(clopidogrel), an irreversible P2Y12 receptor antagonist, is the number one selling drug on the market for antiplatelet therapy [170]. However, P2Y1 is a relatively new target being explored ...
As described above, ticagrelor has been shown to increase plasma levels of adenosine by inhibiting ENT-1. To date, no study demonstrated an adenosine-mediated anti-inflammatory effect of ticagrelor, although ticagrelor was shown to increase the in vitro inhibitory effect of exogenous adenosine on ...
IPA levels are subsequently lower than on the placebo until the administration of the first maintenance dose. Conclusions: Model-based predictions informed the transition from selatogrel subcutaneous administration to oral P2Y12 therapy. The application of modeling techniques illustrates the value of ...