术前和术中血小板功能检测指导心脏手术输血和凝血管理 2017年欧洲心脏病学会成人心脏手术患者血液管理指南建议对出血患者进行抗纤溶治疗(class I,level A);围术期,对出血患者根据床旁即时检测制定治疗方案,可减少输血次数(class IIa,level B)。然而,本指南并未明确在采用粘弹性分析如TEG或Rotem时,启动干预治疗时的临界...
A large body of data supports the contention that the level of on-treatment reactivity according to VerifyNow P2Y12 is a significant risk factor for post-PCI events, although the superiority of intensified antiplatelet therapy based on this test has not been demonstrated in randomized clinical ...
Standard once-daily dosing with aspirin 75–100 mg guarantees a consistent and very high level of COX‑1 inhibition in adherent patients [6]. Fig. 1 Pharmacology of antithrombotic agents in general, and of platelet P2Y12 inhibitors in particular. Reproduced from [5] with permission. 5‑...
Dyspnea, related to ticagrelor therapy mainly develops shortly after the first days of treatment and has been linked to the increased extracellular level of adenosine [44]. In the present trial, early onset of dyspnea cases was reported only in the brand Brilique®. Minor skin rash cases, ...
4C). The P2Y12 blockage led to the reduced level of microglial trans-migration, but the Tau oligomers could reverse the rate of trans-migration even upon P2Y12-blocked conditions (Fig. 4D). Hence, it is evident that P2Y12 signaling can influence the microglial migration while the Tau ...
The current study is an individual patient level pooled data analysis of two independent AMI-dedicated registries: the KAMIR-NIH (Korea Acute Myocardial Infarction Registry-National Institutes of Health) and the KAMIR-V (Korea Acute Myocardial Infarction Registry-V). KAMIR-NIH is a registry that ...
At a significance level of 5% and power of 80%, a total of 1306 participants (653 participants per group) were required. Assuming a 10% dropout rate, a total of 1452 participants (726 participants per group) were required to test our hypothesis. The primary analysis was conducted ba...
(two-tailed Student's t-test).P2RY12 positively regulates the activation and activity of T cells The increased level of IFN-γ in mononuclear lymphocytes (including T cells and NK cells) in the liver has been shown to play a key role in ConA-induced immune hepatitis[41, 42]. We then ...
26 Previous literature has indicated that switching from clopidogrel to ticagrelor modulates the level of microRNAs, which might explain the higher bleeding events in patients under ticagrelor treatment.41 Our meta-analysis significantly updates the literature on P2Y12i plus aspirin in non-cardioembolic ...
The current study is an individual patient level pooled data analysis of two independent AMI-dedicated registries: the KAMIR-NIH (Korea Acute Myocardial Infarction Registry-National Institutes of Health) and the KAMIR-V (Korea Acute Myocardial Infarction Registry-V). KAMIR-NIH is a registry that ...