Meaning These findings suggest that early discontinuation of aspirin and P2Y12 monotherapy was not inferior to 12 months of DAPT, although further research is required in other populations. Abstract Importance P2Y12 inhibitor monotherapy after dual antiplatelet therapy (DAPT; a P2Y12 inhibitor p...
Meaning Although in this study P2Y12 inhibitor monotherapy after a short duration of DAPT resulted in a noninferior rate of major cardiovascular events compared with prolonged DAPT, further research is needed in other populations. Abstract Importance Data on P2Y12 inhibitor monotherapy after short-durat...
while the in- cidence of non-CABG-related TIMI major bleeds was 0.6% and the incidence of all TIMI major bleeds (CABG-related or non-CABG-related) was 1.5% [8]; (2) the time-to-first event analysis based on a 2-sided log- rank test used at a 2-sided significance level (α) ...
Meaning Among patients with CYP2C19 loss-of-function alleles who underwent PCI, genotype-guided selection of an oral P2Y12 inhibitor, compared with conventional clopidogrel therapy, did not significantly reduce ischemic events based on the treatment effect that the study was powered to detect at 12 ...
1-3 The majority of hospitalized patients are not critically ill and do not require intensive care–level support. Although data from a multiplatform randomized clinical trial demonstrated that a therapeutic dose of heparin increased the number of days alive and free of organ support in non–...