Nonparametric statistics were performed with Kruskal–Wallis H, and correction for multiple comparisons performed with Dunn's test. Results In 194 patients, 15 (7.7%) were known to take a P2Y12 inhibitor (clopidogrel in all but one). Patients taking a P2Y12 inhibitor had more HE c...
The first P2Y12 inhibitor tested was ticlopidine, a prodrug that is metabolised in the liver to its active metabolite, but clinical application was terminated because of haematological side effects (agranulocytosis). Its successor drug is clopidogrel, which is also a thienopyridine prodrug that under...
Second, it is a more effective inhibitor of adenosine diphosphate (ADP)-induced platelet aggregation than clopidogrel [10]. Third, the platelet inhibition of ticagrelor is temporary due to its short half-life (8 to 12 h) combined with the reversible receptor binding [11, 12]. Current ...
During the procedure, DES was more frequently used in the potent P2Y12 inhibitors group compared with the clopidogrel group (97.1% versus 91.8%; P < 0.001) and the use of thrombus aspiration or glycoprotein IIb/IIIa inhibitor were not significantly different between the two groups. The ...
What could be interesting going forward, he said, would be to look at whether there exists a subset of patients “who have the more pronounced benefit if treated with a P2Y12 inhibitor alone as compared to aspirin. Because they have a higher risk, we might expect the number needed to trea...
This randomized clinical trial investigates whether P2Y12 inhibitor monotherapy after 3 months of dual antiplatelet therapy (DAPT) was noninferior to 12
10-180 PRU [P2Y12 Reaction Units] - Decreased platelet reactivity to P2Y12 inhibitor. 2. VerifyNow-Aspirin Assay: ≥ 550 Aspirin Reaction Units [ARU] - No evidence of platelet dysfunction due to Aspirin. < 550 Aspirin Reaction Units [ARU] - Platelet dysfunction consistent with Aspirin - detec...
P2Y12 receptor inhibitor plus aspirin versus aspirin treated within 24 h of acute noncardioembolic ischemic stroke or TIA: meta-analysis J Formos Med Assoc (2021), 10.1016/j.jfma.2021.08.006 Google Scholar 11 G.A. Medranda, C. Zhang, G. Doros, C. Yerasi, B.C. Case, W.S. Weintraub,...
multispecific organic anion transporter 3; ACS = acute coronary syndrome; BMI = body mass index; CCB = calcium-channel blocker; CYP = cytochrome P450; ITGB3 = gene encoding integrin beta-3; IRS = insulin receptor substrate; LVF = left ventricular function; PPI = proton-pump inhibitor. ...
During the procedure, DES was more frequently used in the potent P2Y12 inhibitors group compared with the clopidogrel group (97.1% versus 91.8%; P < 0.001) and the use of thrombus aspiration or glycoprotein IIb/IIIa inhibitor were not significantly different between the two groups. The ...