Interpretation Patients taking a P2Y12 inhibitor had more HE and less P2Y12 activity. The effect was most pronounced in patients on DAPT, suggesting a synergistic effect of P2Y12 inhibitors and aspirin with respect to HE. Acute reversal of P2Y12 inhibitors in acute ICH requires further study....
P2Y12 receptor inhibitor plus aspirin versus aspirin treated within 24 h of acute noncardioembolic ischemic stroke or TIA: meta-analysis J Formos Med Assoc (2021), 10.1016/j.jfma.2021.08.006 Google Scholar 11 G.A. Medranda, C. Zhang, G. Doros, C. Yerasi, B.C. Case, W.S. Weintraub,...
Clopidogrel, a P2Y12 inhibitor, is a novel anti-fibrosis agent for chronic kidney disease (CKD), but its mechanisms remain unclear, which we investigated by silencing P2Y12 or treating unilateral ureteral obstruction (UUO) in LysM-Cre/Rosa Tomato mice with clopidogrel in vivo and in vitro. We...
This open-label randomized trial compares the effect of a genotype-guided oral P2Y12 inhibitor selection strategy vs conventional clopidogrel prescribing
Factor & Inhibitor Assays Platelet Function Testing Thrombophilia Testing Fibrinolytic Assays Genetic Tests Miscellaneous Tests Global Tests of Haemostasis Quality Assurance Risk Assessment Algorithms Useful Information Home Page HOME PAGE Data Interpretation App EMBOLUS - THE APP Miscellaneous CON...
This randomized clinical trial investigates whether P2Y12 inhibitor monotherapy after 3 months of dual antiplatelet therapy (DAPT) was noninferior to 12
had higher mCCI scores and had higher proportions of women and patients with a bleeding history than the potent P2Y12 inhibitor groups, whereas the potent P2Y12 inhibitor groups had higher stent counts at the index PCI and higher proportions of patients with MI (Table1; Table S3 in the Supple...
(n = 32). The difference was statistically different in the clopidogrel and ticagrelor condition relative to the control and selatogrel condition, respectively (* = p < 0.05; ns = p > 0.05, Wilcox rank test). (For interpretation of the references to colour in this figure legend, the ...
This randomized noninferiority trial compares the effect of P2Y12 inhibitor monotherapy vs dual antiplatelet therapy (DAPT) on cardiac and cerebrovascular
Asterisks indicate statistical significance at P < .05 for data compared with ADP pretreatment without PKC activator or inhibitor (control; Mann-Whitney U test). We subsequently examined the role of PKC in the desensitization of P2Y1 purinergic receptor–mediated calcium concentration increases in ...