2024年3月，《JAMA Network Open》杂志发表一项研究《P2Y12 Inhibitor Monotherapy vs Dual Antiplatelet Therapy After Deployment of a Drug-Eluting Stent: The SHARE Randomized Clinical Trial》证实了在新一代DES植入后，可以对DAPT的持续时间进行个体化调整，并提供了减少PCI后出血并发症的潜在策略，同时保持了对心...
DAPT,通常为P2Y12受体抑制剂和阿司匹林的联合用药,是PCI后预防血栓形成的标准治疗,但长期DAPT增加了患者出血的风险,为平衡预防缺血性事件和降低出血风险,是否能缩短DAPT疗程呢? 2024年3月,《JAMA Network Open》杂志发表一项研究《P2Y12 Inhib...
Importance P2Y12 inhibitor monotherapy after dual antiplatelet therapy (DAPT; a P2Y12 inhibitor plus aspirin) for a brief duration has recently emerged as an attractive alternative for patients undergoing percutaneous coronary intervention (PCI) with a drug-eluting stent. ...
Drug-herb Synergistic Interactions between Clopidogrel and Natural Medicine Review 作者:Feng, Chengtao;Zhang, Qin;Hou, Jiafu;Liu, Shijuan;Ma, Shitang Introduction:Natural medicine (NM) has been used since ancient times for therapeutic purposes worldwide. Presently, the combination of clopidogrel and ...
2024 P2Y12 Inhibitor Monotherapy vs Dual Antiplatelet Therapy After Deployment of a Drug-Eluting StentThe SHARE Randomized Clinical Trial Pil-Ki Min, MD1; Tae Soo Kang, MD2; Yun-Hyeong Cho, MD3; et al Sang-Sig Cheong, MD4; Byeong-Keuk Kim, MD5; Sung Woo Kwon, MD6; Woo Jung ...
Rationale and design of the comparison between a P2Y12 inhibitor monotherapy versus dual antiplatelet therapy in patients undergoing implantation of coronary drug-eluting stents (SMART-CHOICE): a prospective multicenter randomized trial. Am Heart J. 2018;197:77-84. doi:10.1016/j.ahj.2017.12.002Pub...
The pharmacodynamic effect of P2Y12 receptor antagonists, on or off target, is related to the exposure of the active drug. The active metabolites of the thienopyridines can only be detected in the systemic circulation for about 4 h following intake of the prodrug and then only at levels below...
Also, a crossover study including 56 patients with type 2 diabetes mellitus found plasma levels of miR-197 and miR-223 alongside miR-191 and miR-24 to be lower in diabetic patients on the P2Y12 inhibitor prasugrel, compared with aspirin [26]. We have previously reported a decrease of ...
Platelet inhibitor preparation Where indicated, cancer cell suspensions or washed plate- let suspensions were treated with either 2MeSAMP, an adenosine-based P2Y12 antagonist, or aspirin, a COX-1 antagonist. 2MeSAMP was dissolved in water, while as- pirin was dissolved in 10 % dimethyl ...
However, there is poor evidence on how this compares with administration of a P2Y12 inhibitor after defining coronary anatomy (i.e., downstream administration). Moreover, there are limited head-to-head comparisons of the two P2Y12 inhibitors—ticagrelor and prasugrel—currently recommended by the ...