Objective Hematoma expansion (HE) predicts disability and death after acute intracerebral hemorrhage (ICH). Aspirin and anticoagulants have been associated with HE. We tested the hypothesis that P2Y12 inhibitors predict subsequent HE in patients. We explored laboratory measures of P2Y12 inhi...
. . . We've seen TWILIGHT and other studies have clearly shown when we add aspirin to P2Y12 inhibition, you pay a large penalty in bleeding, and I don't think that a lot of these studies were done at a time when there were standardized approaches to quantifying and measuring bleeding....
Furthermore, previous studies presented that potent P2Y12 inhibitors are also more effective for platelet inhibition in the setting of cardiogenic shock compared with clopidogrel [7, 21]. However, the potential benefit of these agents has never been tested by randomized controlled trials, and ...
Therefore, it has a fast and more predictable platelet inhibition compared with clopidogrel and, thus, is more effective in the prevention of arterial thrombosis, and of stent thrombosis in particular. Ticagrelor is also a platelet P2Y12 inhibitor that binds reversibly to the P2Y12 receptor and ...
Baseline platelet activity [termed BASE] in the absence of platelet P2Y12receptor inhibition is achieved by using a modified Thrombin-receptor Activating Peptide [TRAP] in a reference channel. The results of the assay (TEST) are reported as: ...
As shown in tables 2 and 3 baseline aggregation test using ADP agonist and the % platelet inhibition were comparable between the two groups and remained non-significant shortly after 1 h and 3 h of the loading dose, at day 4 after reaching steady state, 12 and 24 h of the medication dis...
Optimizing P2Y12-receptor inhibition in acute coronary syndrome patients based on platelet function testing: impact of prasugrel and high-dose clopidogrel. J Am Coll Cardiol. 2014. In press.Aradi D, Pinte´r T, Magyari B, Konyi A, Vorobcsuk A, Horvath I, Komo´ csi A. Optimiz- ing ...
Can the PFA-100((R)) be modified to detect P2Y12 inhibition? Pidcock M, Harrison P. M Pidcock,P Harrison - 《Journal of Thrombosis & Haemostasis》 被引量: 40发表: 2006年 Can the PFA-100 be modified to detect P2Y12 inhibition? Diminished therapeutic efficacy and/or 'resistance' to ...
Calmodulin inhibition regulates morphological and functional changes related to the actin cytoskeleton in pure microglial cells. Brain Res Bull. 2016;120:41–57. Article CAS PubMed Google Scholar Li F, et al. The role of P2Y12 receptor inhibition in ischemic stroke on microglia, platelets and ...
Furthermore, previous studies presented that potent P2Y12 inhibitors are also more effective for platelet inhibition in the setting of cardiogenic shock compared with clopidogrel [7, 21]. However, the potential benefit of these agents has never been tested by randomized controlled trials, and ...