However, P2X7R knockdown aggravated osteoprotegerin-induced osteoclast adhesion damage via Ca2+ signaling. In conclusion, the P2X7R鈥揅a2+ NFATc1 signaling pathway has a key functional role in osteoprotegerin-induced osteoclast adhesion structure damage....
通讯作者:伊正君ꎬ电子信箱:ｙｉｚｈｅｎｇｊｕｎ＠１２６.ｃｏｍ Ｐ２Ｘ７Ｒ在结核分枝杆菌感染中的作用研究进展 赵荣兰㊀彭效祥㊀伊正君 摘㊀要㊀结核病是一种全球范围内的人畜共患病ꎬ由结核分枝杆菌(ＭｙｃｏｂａｃｔｅｒｉｕｍｔｕｂｅｒｃｕｌｏｓｉｓꎬＭＴＢ)引起ꎬ其防治形势日趋严峻ꎮ嘌呤能离子...
Changes in intracellular calcium concentration [Ca2+]i are believed to influence the proliferation and differentiation of airway epithelial cells both in vivo and in vitro. In the present study, using mouse alveolar epithelial E10 cells, we demonstrated that the treatment of lung epithelial cells with...
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Song S, Jacobson KN, McDermott KM, Reddy SP, Cress AE, Tang H, Dudek SM, Black SM, Garcia JG, Makino A, Yuan JX (2016) ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells. Am J Physiol Cell Physiol 310:C99–114. https://doi...
When there is ATP binding, P2X7R is gated to the open state to allow the influx of Ca2+ and Na+ ions and the efflux of K+ from cells (Khakh and North, 2006), and results in rapid depolarization of the cells. P2X7R can also promote the release of pro-inflammatory cytokines, ...
当ATP短暂或低浓度刺激时,被激活的P2X7R可以形成阳离子通道,使Na+、Ca2+内流和K+外流。当P2X7R受到ATP持续或高浓度刺激时,成为ATP敏感的P2X7R,在细胞膜上形成非选择性膜孔,允许分子量< 900 Da的大分子和阳离子通过,导致细胞死亡,因此P2X7R又被称为细胞死亡受体[15,19-20]。 2 P2X7R与RA 2.1 P2X7R表达...
Interestingly, Di Virgilio and colleagues reported that amyloidβ peptide (Aβ25–35) triggered increases in intracellular Ca2+, IL-1β release, and plasma membrane permeabilization in microglia derived from wild-type but not P2X7R-deficient mice [2]. However, the results of this study, although...
P2X7R激活后Ca2+内流并触发内质网Ca2+释放,胞内Ca2+浓度升高,或通过Src间接激活Panx1通道,这个通道释放更多的ATP,导致P2X7R的快速和可逆地开放,从而触发一系列细胞反应,如激活半胱氨酸蛋白水解酶‑1和释放IL‑1β等 ,以此介导慢性NP的中枢敏化。 2.4.2 谷氨酸‑NMDAR‑Src‑Panx1...
Stimulation of P2X7 receptors elevates Ca2+ and kills retinal ganglion cells. Invest Ophthalmol Vis Sci. 2005;46(6):2183–2191. doi:10.1167/iovs.05-0052 11. Suzuki T, Hide I, Ido K, Kohsaka S, Inoue K, Nakata Y. Production and release of neuroprotective tumor ...