(2012). Expression of cell cycle regulators P21 and P27 as predictors of disease outcome in colorectal carcinoma. J Gastrointest Cancer 43:279-287.A1-Maghrabi;J;AI-Ahwal;M;Buhmeida;A.Expression of cell cycle regulators P21 and P27 as predictors of disease outcome in colorectal carcinoma.0...
Merkel cell carcinoma (MCC) is an aggressive dermal tumour of neuroendocrine origin with poor prognosis. The role of cell cycle-regulatory proteins (p53/p21/p27) in MCC pathogenesis and their prognostic importance were evaluated. Twenty-four primary MCC specimens with corresponding clinical data were...
Radiation-Induced Senescence-like Growth Arrest Requires TP53 Function but not Telomere Shortening Normal human diploid cells irradiated with X rays showed permanent cell cycle arrest and exhibited senescence-like phenotypes including the expression of s... K Suzuki,I Mori,Y Nakayama,... - 《Radiatio...
Massague´ , Cell-cycle inhibition by independent CDK and PCNA binding domains in p21, Nature 375 (1995) 159-161.Luo Y,Hurwitz J,Massague J.Cell -cycle inhibition by independent CDK and PCNA binding domains in p21.Nature. 1995Cell-cycle inhibition by independent cdk and PCNA binding ...
目的:探讨细胞周期调控系统"Cyclin D1-CDK4/CDK6-p21"在皮肤病理性瘢痕和瘢痕癌中的作用. 方法:(1)采用激光扫描共聚焦显微技术,对瘢痕癌和病理性瘢痕石蜡切片组织进行Cyclin D1和p21免疫荧光双标记,同时采集三维立体图象.(2)应用免疫组织化学染色(SP)法,分别检测瘢痕癌,病理性瘢痕和正常皮肤三组组织中Cyclin D...
Inhibitory Function of p21Cip1/WAF1 in Differentiation of Primary Mouse Keratinocytes Independent of Cell Cycle Control The cyclin-dependent kinase inhibitor p21$^{Cip1/WAF1}$ has been implicated as an inducer of differentiation. However, although expression of p21 is increa... FD Cunto,G Tople...
Diabetes manifests from a loss in functional beta-cell mass, which is regulated by a dynamic balance of various cellular processes, including beta-cell growth, proliferation, and death as well as secretory function. The cell cycle machinery comprised of cyclins, kinases, and inhibitors regulates pr...
In recent years, more and more studies have shown that the function of p21 is dualistic.When p21 is located in the nucleus, it mediates cell cycle arrest and inhibits cell proliferation by inhibitingthe activity of cyclin-dependent kinases (CDKs). However, p21 can promote cell proliferation in...
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The cyclin-dependent kinase inhibitors (CKI) function in mitogenic signaling through their interaction with the cyclins and the cyclin dependent kinases [3], and through proliferating cell nuclear antigen (PCNA) [4]. The CKIs influence apoptosis through interaction with a variety of second messengers...