结果表明G0抑制作为对各种外在和内在应激因素的适应机制存在于不同类型的肿瘤当中,其中胶质母细胞瘤的G0信号表达最高,干细胞分裂率较低的组织更容易出现G0抑制期。G0评分和增殖标志物的表达呈强负相关关系,TP53或DREAM复合体功能缺失,以及p21高表达的样本具有更高的G0评分。 图2. TCGA原发肿瘤样本细胞G0期图谱 癌症...
Lastly, we confirmed expected dependencies on the p53/p21/DREAM activation axis: tumours that were proficient inTP53or the components of the DREAM complex, as well as those with higher p21 expression, had elevated G0 arrest levels across numerous tissues (Fig.2e, Supplementary Fig.2g-h), althou...
RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53–p21 pathway in adipocytes H, Makino H (2012) RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up- regulating the p53-p21(Cip1) pathway in adipocytes... - 《Journal of...
CELL cycleBCL-2 proteinsPEPTIDESMUTANT proteinsLIQUID chromatography-mass spectrometryCELL cycle regulationBREASTBACKGROUND: Porcupine quills, a by‐product of porcupine pork, are rich in keratin, which is an excellent source of bioactive peptides. The objective of this study was to...
In contrast, cyclin E, p21, and p53 were expressed equally at all times. In situ hybridization using PCNA probes further indicated a correlation between PCNA transcription (expression) in the brain and cell cycling. Our evidence thus suggests a potential role for PCNA as an important regulator ...
Our study showed the molecular mechanisms for TF-induced cell growth inhibition and the occurrence of apoptosis in human cancer cells. 2003 Wiley-Liss, Inc. 展开 关键词: apoptosis G0/G1 cell‐cycle arrest terfenadine p53 p21/Cip1 p27/Kip1 ...
RF upregulated Bax, Bad, cleaved caspase 3, p21, and phosphorylated p53 levels. RF induced mitochondrial membrane potential loss and the release of cytochrome c and apoptosis-inducing factor. Cell cycle arrest at G0/G1 phase and the downregulation of Cdk4, Cdk6, and cyclin D1 expression ...
在G0/G1细胞周期阻滞期,p53磷酸化增强并诱导p21表达,导致CDK4、CyclinD1和PCNA表达下调。在线粒体依赖性途径中,上调的p-p53导致Bax/Bcl-2比率升高,并诱导cleaved caspase-3激活,进而触发MDA-MB-231细胞凋亡。我们的结果为WPBFE...
Inourstudy,wefoundthathumancancercellgrowthratewereinhibitedbyterfenadinetreatment.Inordertoinvestigatethemechanismsofterfenadine-inducedcellgrowtharrest,humancellstreatedwithterfenadineandtheresponseofgenesthatregulatedcellcycleweredetermined.Westernblotanalysisrevealedtheterfenadineresultsinaninductionofthep21、p27，andadown...
Protein bound P-cresolhuman umbilical vein endothelial cellscell cyclep21Cip1cyclin D1P-cresol is a typical protein-bound uremic toxin, which is retained in patients with renal failure. It is not known whether protein-bound P-cresol exhibits the toxicity in humans. This study aims to investigate...