Kim, Role of p21 in SP600125-induced cell cycle arrest, endoreduplication, and apoptosis. Cellular and Molecular Life Sciences, 2011. 68(19): p. 3249-3260.MOON D O,CHOI Y H,KIM G Y.Role of p21in SP600125-induced cell cycle arrest,endoreduplication,and apoptosis. Cellular and Molecular ...
Cells from the MRL mouse display DNA damage, cell cycle G2/M arrest, and a reduced level of p21CIP1/WAF. A functional role for p21 was confirmed when tissue injury in an adult p21-/- mouse showed a healing phenotype that matched the MRL mouse, with the replacement of tissues, ...
The dual-specificity phosphatase cell division cycle-25C (CDC25C) plays an important role in the regulation of serine/threonine kinase activity involved in cell cycle. CDC25C can promote mitotic cell G2/M transition by triggering cyclin-dependent kinase-1 (CDK1) dephosphorylation to activate the ...
The role of TNF-α in affecting the fate of tumors is controversial, while some studies have reported apoptotic or necrotic effects of TNF-α, others provide evidence that endogenous TNF-α promotes growth and development of tumors. Understanding the mec
p21(Waf1/Cip1) inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption. During a normal cell cycle, entry into S phase is dependent on completion of mitosis and subsequent activation of cyclin-dependent kinases (Cdks) in G1. Th... ZA Stewart,SD Leach...
Akt regulates proliferation of cells by mTOR signaling and phosphorylating CDK inhibitors p21 and p27. As a serine/threonine kinase, AKT is activated by PI3K or phosphoinositide-dependent kinases (PDK), which is frequently dysregulated in multiple diseases of diabetes, cardiovascular diseases, and ...
Senescent cells from atherosclerotic plaques are lack proliferation, overexpress P16INK4A, P53, P21 [12,13,14], and increase the activity of senescence-associated beta-galactosidase (SAβG) [15]. They can also establish the SASP, which can cause increased secretion of various inflammatory cell ...
A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. Cancer Cell 26, 344–357 (2014). Article CAS PubMed PubMed Central Google Scholar Alexandrov, L.B. et al. Signatures of mutational processes in...
Traumatic Brain Injury (TBI) represents one of the main causes of brain damage in young people and the elderly population with a very high rate of psycho-physical disability and death. TBI is characterized by extensive cell death, tissue damage and neuro
The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers. The expression of CDKs is controlled by a complex regulatory network c