3.1 如附图5所示,随着p-x-7的干预浓度(5、10、20μm)的增加,p-akt(ser473)的表达水平以剂量依赖性方式显著降低(p<0.05)。经20μm p-x-7处理后,p-gsk3b(ser9)的表达水平显著下调(p<0.05),经10、20μm p-x-7处理后,细胞bcl-2表达水平显著下调。此外,pi3k和akt1的表达水平未随着p-x-7的处理而...
3839S GABA(B)R2 Antibody Polyclonal Antibody 100 ul CNY 2,774 4387S DDX5 Antibody Polyclonal Antibody 100 ul CNY 2,774 4918S Ubc9 Antibody Polyclonal Antibody 100 ul CNY 2,774 2009S Phospho-beta-Catenin (Ser33/37) Antibody Polyclonal Antibody 100 ul CNY 3,487 3359S Phospho-Torc1/Crt...
a Protein levels of total β-catenin, cytoplasmic β-catenin, and nuclear β-catenin as determined by western blotting. GAPDH was used as the loading control for the total and cytoplasmic protein. Lamin A was used as the loading control for nuclear protein. bβ-Catenin-driven transcription acti...
3839S GABA(B)R2 Antibody Polyclonal Antibody 100 ul CNY 2,774 4387S DDX5 Antibody Polyclonal Antibody 100 ul CNY 2,774 4918S Ubc9 Antibody Polyclonal Antibody 100 ul CNY 2,774 2009S Phospho-beta-Catenin (Ser33/37) Antibody Polyclonal Antibody 100 ul CNY 3,487 3359S Phospho-Torc1/Crt...
ishevelled(散乱的)蛋白导致GSK3B失活,使α-catenin避免被磷酸化而遭降解的命运 , β-catenin才能在胞质中积累起来。 当胞质中B-catenin的浓度达到一定水平时, 就可向细胞核转移。在胞核中β-caten in与转录因子家族Tcf /Lefs结合, 可激活cyc linD1 ...
Thermo-life PA517916 PHOSPHO-BETA-CATENIN PTHR41/SE R45 ￥3,613.00 R45 Thermo-life PA518174 ANTI-FOXI1/FKHL10 EA ￥3,613.00 EA Thermo-life PA518202 ANTI-FANCF EA ￥3,613.00 EA Thermo-life PA518289 ANTI-SPROUTY EA ￥3,613.00 EA Thermo-life PA518359 ANTI-NEUROSERPIN EA ￥3,613.00 EA...
GSK-3 is inhibited in response to two main activating stimuli, specifically the insulin and Wnt signalling pathways. Main substrates of GSK-3β are glycogen synthase (GS), β-catenin, and Tau protein [4,5]. GSK-3β can phosphorylate at least 15 residues of Tau protein: Ser46, Thr50, ...
Western analysis was carried out to detect the total and phosphorylated forms of AKT, JNK, GSK3b, b-catenin, FOXO1 and PDCD4. b-actin was used as control. The relative levels of inflammatory cytokines and chemokines, and specific inflammatory microRNAs (miRNAs) were analyzed by real time PCR...
et al. C-X-C motif chemokine receptor 4 aggravates renal fibrosis through activating JAK/STAT/GSK3β/β-catenin pathway. J. Cell. Mol. Med. 24, 3837–3855. https://doi.org/10.1111/jcmm.14973 (2020). 41. Yuan, A., Lee, Y., Choi, U., Moeckel, G. & ...
TGF-beta1 targets the GSK-3beta/ beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts. Pharmacol Res 2008;57: 274–282. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material...