2.上颚 β-catenin介导的Wnt信号通路涉及各种组织和器官的发育,包括颅面结构[5]。在小鼠胚胎发育过程中,Gsk-3β对于上颚形成至关重要,Gsk-3β在调节胚胎干细胞系中的Wnt/βcatenin信号传导中发挥冗余功能[6]。Gsk-3β突变杂合子的小...
mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling...
2.上颚 β-catenin介导的Wnt信号通路涉及各种组织和器官的发育,包括颅面结构[5]。在小鼠胚胎发育过程中,Gsk-3β对于上颚形成至关重要,Gsk-3β在调节胚胎干细胞系中的Wnt/βcatenin信号传导中发挥冗余功能[6]。Gsk-3β突变杂合子的小鼠看起来正常且有生育能力,但通过Gsk3b+/-小鼠之间的杂交获得的Gsk3b-/-小鼠...
在小鼠胚胎发育过程中,Gsk-3β对于上颚形成至关重要,Gsk-3β在调节胚胎干细胞系中的Wnt/βcatenin信号传导中发挥冗余功能[6]。Gsk-3β突变杂合子的小鼠看起来正常且有生育能力,但通过Gsk3b+/-小鼠之间的杂交获得的Gsk3b-/-小鼠表现出完全的腭裂缺陷并在出生后24小时内死亡。为了确定Gsk-3β在腭发生过程中的...
mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling...
Mao, Y., et al., Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell, 2009. 136(6): p. 1017-31.Mao Y, Ge X, Frank CL, et al. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation ...
N-glycosylation of CD82 at Asn157 is required for suppressing migration and invasion by reversing EMT via Wnt/β-catenin pathway in colon cancer Authors - Lin Zhu View Article human WB Front Pharmacol Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway Authors...
Cat No. 22104-1-AP Publications(368) Host / Isotype Rabbit / IgG Reactivity human, mouse, rat and More (5) Applications WB, IHC, IF/ICC, IP, ELISA and More (3) Synonyms GSK3 beta, GSK3A B, GSK-3 beta, GSK 3 beta, EC:2.7.11.26 Formulation: PBS and Azide PBS and Azide...
beta cateninexpression and rendered the cells more similar to blast crisis CML cells when studied in in vivo models (Abrahamsson et al., 2009). On the other hand, introducing WT GSK3 into blast crisis CML cells was shown to reduce beta catenin and these cells displayed reduced leukemia...
GSK-3 beta/GSK3B 蛋白分子量&等电点 Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) Homo sapiens (Human). 参数根据以下信息计算得出 FT CHAIN 1-420 Glycogen synthase kinase-3 beta. ...