Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 2009; 136:1017-1031. [PubMed: 19303846]Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, et al. Disrupted in schizophrenia 1 regulates neuronal progenitor ...
Down-regulation of the AKT/GSK3b/b-catenin signalling pathway by the triterpene ursolic acid induced intrinsic apoptosis in human soft tissue sarcomasAlemanyR.VillarV. H.VoglerO.SerraJ. M.MartinJ.CHEMISTRY AND PHYSICS OF LIPIDS
Data are presented as a percentage of the total number of insulin þ cells counted.13 Western Blot Analysis Protein level of Akt, Gsk3b, b-catenin, cyclin D1 and Pdx-1 in both pancreata and islets from c-Kit þ / þ and c-KitWv/ þ mice at 8 weeks of age with or without...
GNF7156 induced b-catenin nuclear translocation (Fig. 4a), consistent with cellular Gsk3b inhibition. Induction of rat b-cell proliferation by GNF7156 was blunted by ectopic expression of wild-type or constitutively active Gsk3b (ref. 29), but less by kinase-dead Gsk3b (ref. 30; Fig. 4b...
In addition, the 6-methylcoumarin activated GSK3β and β-catenin phosphorylation and reduced the β-catenin protein level. These results suggest that 6-methylcoumarin stimulates melanogenesis through the GSK3β/β-catenin signal pathway, thereby affecting the pigmentation process. Finally, we tested ...
Activation of Wnt/b-catenin/GSK3b signaling during the development of diabetic cardiomyopathyXi, XHWang, YLi, JWang, FWTian, GHYin, MSMu, YLChong, ZZXi, X. HX. H. Xi, Y. Wang, J. Li et al., "Activation of Wnt/𝛽- catenin/GSK3𝛽 signaling during the development of diabetic...
Using an in vitro tumor cell emboli culture paradigm (3D), we found that COX-2 or its metabolite PGE2 increased AKT activity and the inhibitory phosphorylation on GSK3尾 that prevents degradation of p120 catenin (CTNND1), a stabilizer of E-cadherin adhesion complexes. Conversely, the COX-2 ...
Salmanian S, Najafi SM, Rafipour M, Arjomand MR, Shahheydari H, Ansari S, Kashkooli L, Rasouli SJ, Jazi MS, Minaei T. Regulation of GSK-3b and b-catenin by Gaq in HEK293T cells. Biochem. Biophys. Res. Commun. 2010; 395:577-582. [PubMed: 20399743]...
S.M.A. Najafi, Activators of G proteins inhibit GSK-3b and stabilize b-catenin in Xenopus oocytes, Biochem. Biophys. Res. Commun. 382 (2009) 365-369.Mahmoud A S N. Activators of G proteins inhibit GSK-3β and stabilize β-catenin in Xenopus oocytes[J].Biochemical and Biophysical ...
Cigarette smoke extract induces activation of b-catenin/TCF signaling through inhibiting GSK3b in human alveolar epithelial cell lineTian, D.Zhu, M.Li, J.Ma, Y.Wu, R.TOXICOLOGY LETTERS