简单来说,wnt/beta-catenin通路是用来调控细胞增殖,细胞极性,以及控制细胞命运的基础通路,能够维持胚胎和组织发育的内稳态(homeostasis)。在这条通路中,外泌糖脂蛋白Wnt作为信号分子,与细胞膜表面受体LRP5/6以及Frizzled结合,激活细胞内通路下游的关键蛋白,GSK3,Axin等,从而调控“中间人” beta-catenin的蛋白分解,进一...
没有Wnt信号的时候,胞内游离的Beta catenin会被Axin和APC识别,然后Axin和APC折叠Beta catenin,导致几个磷酸位点暴露出来,接着CK1就会跑过来把Beta catenin的Ser45位磷酸化,然后GSK3beta也跟上来磷酸化3个地方(Thr41,Ser37,Ser33),接着Beta catenin就会被E3泛素化连接酶识别,被打上泛素化标签最后被蛋白酶降解。
KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) 是一种具有口服活性的 CXXC5-DVL (IC50:19 nM) 和 GSK3β (IC50:10 nM) 的双重抑制剂。它通过对 CXXC5-DVL 相互作用和 GSK3β 活性的抑制作用激活 Wnt/β-catenin 信号传导...
Canonical Wnt/β-catenin pathway: “WNT ON state”: WNT proteins, by binding to frizzled receptors and the LRP co-receptor, act to suppress the activity of glycogen synthase kinase-3β (GSK-3β). ZNRF3 promotes degradation of WNT receptor functioning as tumor suppressors. This prevents phospho...
EMT. Loss of E-cadherin expression or loss of function of either APC,axinor GSK3β leads to a reduced degradation and subsequent overexpression of free cytoplasmic β-catenin, which can exert its nuclear function without control (Schmalhofer et al., 2009)....
碧云天生物技术有限公司生产的Beta-Catenin Rabbit Monoclonal Antibody,产品编号产品名称产品包装产品价格AF1189Beta-CateninRabbitMonoclonalAntibody50μl询价来源用途交叉反应性分子量Rabb
Furthermore, this fibrosis promotion by FSH was through activation of AKT/GSK-3β/β-catenin pathway that could be attenuated by silence of FSHR by siRNA or LY294002. Besides, FSH-stimulated HK-2 secreted chemokines, such as IL-8, promoted macrophages migration to exacerbate tubulointerstitial ...
CHIR-99021 (CT99021) 是一种 Wnt/β-catenin 信号通路激活剂,也是一种 GSK-3α/β抑制剂 (IC50=10/6.7 nM),具有选择性和口服活性。CHIR-99021 可以诱导细胞自噬,可增强小鼠和人类胚胎干细胞的自我更新。 AutophagyGSK-3Wnt/beta-catenin ¥ 318 ...
Wnt agonist 1 does not inhibit the activity of GSK-3β, and may be a useful tool in the study of physiological processes that involve the Wnt pathway. [1] In vivo In a Xenopus model, Wnt agonist 1 (10 μM) mimics the effects of Wnt at the whole-organism level, and affects Xenopus...
CHIR-99021 (CT99021) 是一种 Wnt/β-catenin 信号通路激活剂,也是一种 GSK-3α/β抑制剂 (IC50=10/6.7 nM),具有选择性和口服活性。CHIR-99021 可以诱导细胞自噬,可增强小鼠和人类胚胎干细胞的自我更新。 AutophagyGSK-3Wnt/beta-catenin ¥ 318 ...