Rab11a sustains GSK3beta/Wnt/beta-catenin signaling to enhance cancer progression in pancreatic cancer. Tumour biology. 2016; 37:13821-13829.Yu L, Li X, Li H, et al. Rabl la sustains GSKβ/Wnt/β-catenin signaling to enhance cancer progression in pancreatic cancer [J]. Tumour Biol, ...
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII)是具有有效和选择性的 GSK-3β 抑制剂 ,IC50值为 64 nM。GSK-3β inhibitor 8 是一种噻吩嘧啶衍生物,负调控 Wnt 信号通路,刺激 β 细胞增殖。 规格价格库存数量 1 mg¥ 77035日内发货 大包装 & 定制 ...
BMC Research Notes 2014, 7:273 http://www.biomedcentral.com/1756-0500/7/273 RESEARCH ARTICLE Open Access Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors Ortwin Naujok*, Jana Lentes, Ulf Diekmann,...
Background: As Wnt/beta-catenin/glycogen synthase kinase 3 beta (GSK3 beta) signaling has been implicated inmyocardial injury and diabetic cardiomyopathy (DCM) is a major part of diabetic cardiovascular complications, we therefore investigated the alterations of Wnt/beta-catenin/GSK3 beta signaling ...
Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta. Rask K,Nilsson A,Br?nnstr?m M,Carlsson P,Hellberg P,Janson P-O,Hedin L,Sundfeldt K. British Journal of Cancer . 2003Rask K,,Nilsson A,Brannstrom M,Carlsson P.Wnt-signalling pathway ...
1998. Axin, a negative regulator of the Wnt sig- naling pathway, forms a complex with GSK-3beta and beta- catenin and promotes GSK-3beta-dependent phosphoryla- tion of beta-catenin. EMBO J. 17: 1371-1384.Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A: Axin, a ...
Qiu, MicroRNA-26b inhibits cell proliferation and cytokine secretion in human RASF cells via the Wnt/GSK-3 beta/beta-catenin pathway, Diagn. Pathol. 10 (2015).Sun J, Yan P, Chen Y, Chen Y Yang J, Xu G, Mao H, Qiu Y. MicroRNA-26b inhib...
Katoh M, Katoh M (2006) Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. Cancer Biol Ther 5(9):1059–1064Katoh M, Katoh M: Cross-talk of WNT and FGF signaling pathways at GSK3β to regulate β-catenin and SNAIL signaling...
There were significant increases of beta-catenin and GSK3beta, while APC was reduced in ovarian cancer compared to the normal ovary. Beta-catenin and Lef-1 were coimmunoprecipitated in ovarian tumours, but not in the normal ovary. Nuclear localisation of beta-catenin or Lef-1 could not be ...
WNT/GSK-3 beta/beta-cateninGastric cancerXanthoangelol and 4-hydroxyderricinBackground Glutamyl-prolyl-tRNA synthetase (EPRS/GluRS) is primarily part of the multi-synthetase complex that may play a key role in cancer development. However, the biological function, molecular mechanism, and inhibitor ...