CHIR-99021 (CT99021) 是一种 Wnt/β-catenin 信号通路激活剂,也是一种 GSK-3α/β抑制剂 (IC50=10/6.7 nM),具有选择性和口服活性。CHIR-99021 可以诱导细胞自噬,可增强小鼠和人类胚胎干细胞的自我更新。 AutophagyGSK-3Wnt/beta-catenin ¥ 318 现货 规格 数量 客户已引用 4-Chloro-2'-bromoacetophe...
GSK-3β在能量代谢、体型发育(body pattern development)和神经细胞发育过程中起重要作用。 GSK-3β可以磷酸化β-catenin并调控Wnt信号通路,还可以调节cyclin D1的蛋白降解和细胞内定位。GSK-3β的生物学特性:GSK-3最早在兔骨骼肌的分次提取物中被分离出来,主要有两种亚型,即GSK-3α和GSK-3β,二者在催化区域具...
mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling...
GSK-3 beta/GSK3B 蛋白分子量&等电点 Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) Homo sapiens (Human). 参数根据以下信息计算得出 FT CHAIN 1-420 Glycogen synthase kinase-3 beta. 分子量 (Da) 46744.34 理论PI值 8.98 GS...
Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization ...
p-GSK-3β抗体(2D3)是一种小鼠单克隆IgG1抗体,可通过蛋白质印迹(WB)和免疫沉淀(IP)检测小鼠、大鼠和人类样本中的糖原合酶激酶-3β(GSK-3β)。抗磷酸化GSK-3β抗体(2D3)可特异性识别磷酸化形式的GSK-3β,后者在能量代谢、细胞增殖和细胞凋亡调节等多种细胞过程中发挥着关键作用。GSK-3β主要位于细胞质中...
Furthermore, this fibrosis promotion by FSH was through activation of AKT/GSK-3β/β-catenin pathway that could be attenuated by silence of FSHR by siRNA or LY294002. Besides, FSH-stimulated HK-2 secreted chemokines, such as IL-8, promoted macrophages migration to exacerbate tubulointerstitial ...
Thus, GSK-3β may play a critical role in regulating β-catenin stability during development and tumor progression. It is responsible for rapid cyclin D1 turnover by phosphorylating it on Thr-286. It functions as a negative regulator of Wnt signaling during embryonic development and cell ...
Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. 来自 Taylor & Francis 喜欢 0 阅读量: 97 作者:M Katoh,M Katoh 摘要: WNT and FGF signaling pathways cross-talk during a variety of cellular processes, such as human colorectal ...
GSK3β是在1980年做为糖原合成酶抑制分子被发现,随后发现其广泛参与了细胞增殖、干细胞更新、凋亡和及发育的过程,通过胰岛素、Wnt/β-catenin和Hedgehog等信号通路发挥作用,与神经系统紊乱、糖尿病和炎症等疾病和病理过程有着密切关系。在肾脏疾病,有报道发现GSK3β参与了肾细胞凋亡和炎症相关通路。