GSK-3 betabeta-CateninAstragaloside IV (AS-IV) is an active ingredient in Astragalus membranaceus and is involved in various biological processes, such as regulating the immune system, and counteracting inflammation and malignancy. The aim of this study was to explore the effect of AS-IV on non...
KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) 是一种具有口服活性的 CXXC5-DVL (IC50:19 nM) 和 GSK3β (IC50:10 nM) 的双重抑制剂。它通过对 CXXC5-DVL 相互作用和 GSK3β 活性的抑制作用激活 Wnt/β-catenin 信号传导...
Furthermore, this fibrosis promotion by FSH was through activation of AKT/GSK-3β/β-catenin pathway that could be attenuated by silence of FSHR by siRNA or LY294002. Besides, FSH-stimulated HK-2 secreted chemokines, such as IL-8, promoted macrophages migration to exacerbate tubulointerstitial ...
Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. 来自 Taylor & Francis 喜欢 0 阅读量: 97 作者:M Katoh,M Katoh 摘要: WNT and FGF signaling pathways cross-talk during a variety of cellular processes, such as human colorectal ...
BMC Research Notes 2014, 7:273 http://www.biomedcentral.com/1756-0500/7/273 RESEARCH ARTICLE Open Access Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors Ortwin Naujok*, Jana Lentes, Ulf Diekmann...
Pharmacology Cross-talk between cAMP/PKA and GSK3beta/beta-catenin signaling in corpus luteum progesterone synthesis UNIVERSITY OF NEBRASKA MEDICAL CENTER John S. Davis RoyLynnProgesterone secretion by the steroidogenic cells of the corpus luteum (CL) is essential for reproduction. Progesterone synthesis...
Xiong Zhang,Lu Si,Yu Li,Can Mi.Expressions of GSK-3beta, Beta-catenin and PPAR-gamma in medulloblastoma[J]. Chinese Journal of Cancer Research .2009(3)Xiong Zhang,Lu Si,Yu Li,Can Mi.  Expressions of GSK-3beta, Beta-catenin and PPAR-gamma in medulloblastoma[J]. Chinese Journal of...
摘要: Reports on the binding of glycogen synthase kinase 3beta (GSK3beta) to the adenomatous polyposis coli gene (APC)-beta-catenin complex and regulation of the complex assembly in Drosophila. Effect of excess beta-catenin; Phosphorylation sites; Dependence of binding on phosphorylation....
GSK-3β-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by β-catenin and protein phosphatase 2A complexed with Axin. GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed...
Expression of GSK-3beta,Beta-catenin, and PPAR-gamma in medulloblastoma. Chin J of Cancer Res. Vol 21 (2009).p 235Zhang X,Si L,Li Y. Expressions of GSK-3beta,Beta-Catenin and PPAR-Gamma in Medulloblastoma[J].Chinese Journal of Cancer Research 2009,21....