AS-IV also promoted cleavage of caspase-3, another indication of apoptosis. Finally, the Akt/GSK-3 beta/beta-catenin axis was suppressed in response to AS-IV. Taken together, these fmdings provide evidence that AS-IV inhibits NSCLC development via inhibition of the Akt/GSK-3 beta/beta-...
Furthermore, this fibrosis promotion by FSH was through activation of AKT/GSK-3β/β-catenin pathway that could be attenuated by silence of FSHR by siRNA or LY294002. Besides, FSH-stimulated HK-2 secreted chemokines, such as IL-8, promoted macrophages migration to exacerbate tubulointerstitial ...
This suppression was attributed to the inhibition of AKT/GSK-3beta phosphorylation, leading to decreased beta-catenin stability and activity. Additionally, ergosterol treatment impacted protein synthesis and ubiquitination, potentially contributing to its anti-cancer effects. Moreover, the study revealed ...
Activation of Akt significantly stimulated GSK-3 beta/beta-catenin signaling and thus decreased PPAR gamma expression and adipogenesis of RCT-FAPs, while the inhibition effect was attenuated by beta-catenin inhibitor. Furthermore, Wnt signaling activator BML-284 limited adipogenesis of RCT-FAPs, ...
SLFN5 knockdown activated AKT/GSK-3 beta/beta-catenin pathway by promotion AKT phosphorylation and subsequent GSK-3 beta phosphorylation, further beta-catenin translocation into nucleus as un-phosphorylated protein at Ser33, 37 and 45 and Thr41 sites. This is the first study to report that SLF...
Hyperactivation of Akt/GSK3beta/beta-catenin signaling in adiponectin haplodeficient tumors.Janice B. B. LamKim H. M. ChowAimin XuKaren S. L. LamJing LiuNaiSum WongRandall T. MoonPeter R. ShepherdGarth J. S. CooperYu Wang
beta-CateninAims: Atrial fibrosis is a common feature of atrial fibrillation (AF). Recently, it is reported that osteopontin (OPN) can induce fibrosis in lungs, livers and kidneys. However, its role in atrial fibrosis remains unclear. Here, we sought to determine the involvement of OPN in ...
LIMD2 overexpression results in the stimulation of the phosphorylation of GSK-3 beta on Ser-9, as well as of Akt on Ser-473, in an ILK-dependent manner. Furthermore we demonstrate a striking LIMD2 induced stimulation of phosphorylation of beta-catenin on Ser-552, shown previously to be a...
TL-2 attenuates b-amyloid induced neuronal apoptosis through the AKT/GSK-3b/b-catenin pathway. Int J Neuropsychopharmacol 2014;17: 1511-1519.Zhu X, Wang S, Yu L, Yang H, Tan R, Yin K, et al. TL-2 attenuates beta-amyloid induced neuronal apo- ptosis through the AKT/GSK-3beta/beta-...
Zhao, Activation of Akt/GSK-3beta/ beta-catenin signaling pathway is involved in survival of neurons after traumatic brain injury in rats, Neurol. Res. 34 (2012) 400-407.Zhao,S.,Fu,J.,Liu,X.,Wang,T.,Zhang,J.,Zhao,Y.. Activation of Akt/GSK-3beta/beta-catenin signaling pathway is ...