Oxoglutarate dehydrogenase-like (OGDHL) is considered to be the isoenzyme of oxyglutarate dehydrogenase (OGDH) in the OGDH complex, which degrades glucose and glutamate. OGDHL was reported to reprogram glutamine metabolism to suppress HCC progression in an enzyme-activity-dependent manner. However, ...
建议收到该Oxoglutarate Dehydrogenase-Like (OGDHL) Antibody产品后,储存温度为-20°C。避免重复冻融其他 Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白质供应商,致力于为生命科学、药物开发和生物技术领域的科学家和研究者提供最佳的客户体验和高质量的产品。产品涵盖一抗、二抗、蛋白质、ELISA...
In contrast to the heart complex, where only the known OGDH was determined, the band corresponding to the brain OGDH component was found to also include the novel 2-oxoglutarate dehydrogenase-like (OGDHL) protein. The ratio of identified peptides characteristic of OGDH and OGDHL was preserved ...
AMA: antimitochondrial autoantibody; ANA: antinuclear autoantibody; BCOADC-E2: E2 subunit of branched chain 2-oxo-acid dehydrogenase complex; E3BP: dihydrolipoamide dehydrogenase (E3)-binding protein; OGDC-E2: E2 subunit of the oxoglutarate dehydrogenase complex; PBC: primary biliary cirrhosis; PDC-E2...
Moreover, cancer-specific metabolic changes, such as those that occur subsequent to mutations in the genes encoding succinate dehydrogenase, fumarate hydratase or isocitrate dehydrogenase, can dysregulate specific 2OGDDs. This latter observation suggests that the role of 2OGDDs in cancer extends beyond...
A novel regulatory mechanism for control of the ubiquitous 2-oxoglutarate dehydrogenase complex (ODH), a key enzyme of the tricarboxylic acid cycle, was discovered in the actinomycete Corynebacterium glutamicum, a close relative of important human pathogens like Corynebacterium diphtheriae and Mycobacterium...
M1PDH-mannitol-1-phosphate dehydrogenase; M1Pase-mannitol-1-phosphatase.; DHAP-dihydroxyacetone phosphate; GHD-gutathione; ROS-reactive oxygen species; LOXs-lipoxygenase; AOS-allene oxide synthase; OPDA-12-oxo-Phytodienoic acid; HpETE-12-hydroperoxy-eicosatetraenoic acid; HpOTrE-13-hydroperoxy octad...
Actinobacteria possess unique ways to regulate the oxoglutarate metabolic node. Contrary to most organisms in which three enzymes compose the 2-oxoglutarate dehydrogenase complex (ODH), actinobacteria rely on a two-in-one protein (OdhA) in which both the
For instance, glutamate dehydrogenase (GDH) downregulation has been shown to deplete 2-OG levels impairing the antioxidant enzyme GSH peroxidase 1, resulting in increased oxidative stress in lung and breast cancer cells [49]. Fumarate accumulation due to FH mutations associated with increased tumor ...
It has been suggested that this inborn error of catabolism of lysine, tryptophan, and hydroxylysine (27) may be due to 2-oxoadipate dehydrogenase deficiency, but such a defect has not been demonstrated directly. The yeast strains used in the present investigation are devoid of the LYS2 gene,...