Oxoglutarate dehydrogenase-like (OGDHL) is considered to be the isoenzyme of oxyglutarate dehydrogenase (OGDH) in the OGDH complex, which degrades glucose and glutamate. OGDHL was reported to reprogram glutamine metabolism to suppress HCC progression in an enzyme-activity-dependent manner. However, ...
建议收到该Oxoglutarate Dehydrogenase-Like (OGDHL) Antibody产品后,储存温度为-20°C。避免重复冻融其他 Abbexa总部位于英国剑桥的剑桥科学园,是一家专业的全球抗体供应商和蛋白质供应商,致力于为生命科学、药物开发和生物技术领域的科学家和研究者提供最佳的客户体验和高质量的产品。产品涵盖一抗、二抗、蛋白质、ELISA...
In contrast to the heart complex, where only the known OGDH was determined, the band corresponding to the brain OGDH component was found to also include the novel 2-oxoglutarate dehydrogenase-like (OGDHL) protein. The ratio of identified peptides characteristic of OGDH and OGDHL was preserved ...
AMA: antimitochondrial autoantibody; ANA: antinuclear autoantibody; BCOADC-E2: E2 subunit of branched chain 2-oxo-acid dehydrogenase complex; E3BP: dihydrolipoamide dehydrogenase (E3)-binding protein; OGDC-E2: E2 subunit of the oxoglutarate dehydrogenase complex; PBC: primary biliary cirrhosis; PDC-E2...
Moreover, cancer-specific metabolic changes, such as those that occur subsequent to mutations in the genes encoding succinate dehydrogenase, fumarate hydratase or isocitrate dehydrogenase, can dysregulate specific 2OGDDs. This latter observation suggests that the role of 2OGDDs in cancer extends beyond...
Helicobacter pylori, a major cause of human gastric disease, is a microaerophilic bacterium that contains neither pyruvate nor 2-oxoglutarate dehydrogenase activity. Previous studies (N. J. Hughes, P. A. Chalk, C. L. Clayton, and D. J. Kelly, J. Bacteriol. 177:3953-3959, 1995) have in...
During osmotic stress and hypoxia, the accumulation of proline (Pro) and alanine (Ala), respectively, promotes the transcriptional regulation of genes involved in their degradation, such as proline dehydrogenase (PDH), to compensate for their sudden increases in the cell under stress. Interesting...
Rice JE, Dunbar B, Lindsay JG (1992) Sequences directing dihydrolipoamide dehydrogenase (E3) binding are located on the 2-oxoglutarate dehydrogenase (E1) component of the mammalian 2-oxoglutarate dehydrogenase multienzyme complex. EMBO J 11:3229-3235...
It has been suggested that this inborn error of catabolism of lysine, tryptophan, and hydroxylysine (27) may be due to 2-oxoadipate dehydrogenase deficiency, but such a defect has not been demonstrated directly. The yeast strains used in the present investigation are devoid of the LYS2 gene,...
1998. Crystal structure of the truncated cubic core component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex. J. Mol. Biol. 280:655-668.Knapp JE, Mitchell DT, Yazdi MA, Ernst SR, Reed LJ, Hackert ML (1998) Crystal structure of the truncated cubic core component of...