Oxoglutarate dehydrogenase-like (OGDHL) is considered to be the isoenzyme of oxyglutarate dehydrogenase (OGDH) in the OGDH complex, which degrades glucose and glutamate. OGDHL was reported to reprogram glutamine metabolism to suppress HCC progression in an enzyme-activity-dependent manner. However, ...
Also, the activity level of ODHC (2-oxoglutarate dehydrogenase complex) affected the flux distribution at the branch point of 2-oxoglutarate and glutamate synthesis, primarily by reductive amination in the presence of ammonia and NADPH. Increasing glutamate dehydrogenase (GDH) has no effect on ...
2-Oxoglutarate activates transcription of theogdhgene in humans (Koike, 1998). Theogdhlgene encoding for the 2-oxoglutarate-dehydrogenase-like isoenzyme expressed in the brain, is hypermethylated in various tumors, with increased expression of 2-oxoglutarate-dehydrogenase-like deleterious for proliferatio...
2-oxoacid dehydrogenase complexes have long made a textbook example of megadalton-sized, universally conserved multienzymatic machineries, each dedicated to specific, yet conserved, three-step reactions located at the core of central metabolism. These complexes have, so far, been thought to be center...
Moreover, cancer-specific metabolic changes, such as those that occur subsequent to mutations in the genes encoding succinate dehydrogenase, fumarate hydratase or isocitrate dehydrogenase, can dysregulate specific 2OGDDs. This latter observation suggests that the role of 2OGDDs in cancer extends beyond...
Mitochondrial 2-oxoglutarate (α-ketoglutarate) dehydrogenase complex (OGDHC), a key regulatory point of tricarboxylic acid (TCA) cycle, plays vital roles in multiple pathways of energy metabolism and biosynthesis. The catalytic mechanism and allosteric
Rice JE, Dunbar B, Lindsay JG (1992) Sequences directing dihydrolipoamide dehydrogenase (E3) binding are located on the 2-oxoglutarate dehydrogenase (El) component of the mammalian 2-oxoglutarate dehydrogenase multienzyme complex. EMBO J 11:3229-3235...
Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts2-Oxoglutarate dehydrogenase2-Oxoglutarate phosphonate analogues
A novel regulatory mechanism for control of the ubiquitous 2-oxoglutarate dehydrogenase complex (ODH), a key enzyme of the tricarboxylic acid cycle, was discovered in the actinomycete Corynebacterium glutamicum, a close relative of important human pathogens like Corynebacterium diphtheriae and Mycobacterium...
Because cyanobacteria lack a 2-oxoglutarate dehydrogenase [19], the main metabolic role for 2-oxoglutarate in these microorganisms is incorporation of nitrogen through the glutamine synthetase–glutamate synthase cycle [20]. Therefore, 2-oxoglutarate is considered to be particularly well suited to act ...