2-Oxoglutarate dehydrogenase (ogdh gene) is an ubiquitous enzyme with additional isoenzymes (ogdhl and dhtkd1 genes) characterized in animals. Using thiamine (vitamin B1) diphosphate, the isoenzymes catalyze oxidative decarboxylation of 2-oxoglutarate or 2-oxoadipate. The coupled generation of ...
The activity of the pyruvate dehydrogenase complex, 2-oxoglutarate dehydrogenase, and branched-chain keto acid dehydrogenase were all reduced to levels 9 to 29% of control. In contrast, the activity of lipoamide dehydrogenase was normal. The conversion of 1-C-leucine and 1-C-valine toCOand of...
AMA: antimitochondrial autoantibody; ANA: antinuclear autoantibody; BCOADC-E2: E2 subunit of branched chain 2-oxo-acid dehydrogenase complex; E3BP: dihydrolipoamide dehydrogenase (E3)-binding protein; OGDC-E2: E2 subunit of the oxoglutarate dehydrogenase complex; PBC: primary biliary cirrhosis; PDC-E2...
The 2-oxoglutarate dehydrogenase complex (OGDHc) orchestrates a critical reaction regulating the TCA cycle. Although the structure of each OGDHc subunit has been solved, the architecture of the intact complex and inter-subunit interactions still remain unknown. Here we report the assembly of native,...
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Glutamate dehydrogenase activity assay 300 µg protein of synaptosomes prepared in Krebs-like buffer were used. Final concentrations of glutamate (Sigma, G1251) and NADP (Sigma, N5755) were 1 mM each. Total final volume per well in the black clear-bottom 96-well plate (Greiner Bio-One, ...
isocitrate dehydrogenase2‐oxoglutarate dehydrogenasemalic enzymeHeLa cellsThe effects of methotrexate (MTX) on oxygen uptake by permeabilized HeLa cells were evaluated. MTX did not inhibit state III respiration when the oxidizable substrate was succinate, but when the substrates were 2-oxoglutarate or ...
酮戊二酸脱氢酶(OGDH)重组蛋白 价格: ￥2580/毫克 产品详情:中文名称:酮戊二酸脱氢酶(OGDH)重组蛋白英文名称:RecombinantOxoglutarateDehydrogenase(OGDH)英文简称:OGDH规格:10μg50μg2... 货号:ZY187Ra011 品牌:HZbscience 产地:中国/美国 脱氢酶相关产品报价 更多> 产品标题 价格 产地 公司名称 更新日期 ...
Bunik VI, Degtyarev D (2008) Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins. Proteins Struct Funct Bioinforma 71:874–890. https://doi.org/10.1002/prot.21766 11. B...
2-Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play diverse roles in many biological processes, including regulation of hypoxia-inducible factor-mediated adaptation to hypoxia, extracellular matrix formation, epigenetic regulation of gene transcription and the reprogramming ...