Effect of lysine succinylation on the regulation of 2-oxoglutarate dehydrogenase inhibitor, OdhI, involved in glutamate production in Corynebacterium glutamicum\n Corynebacterium glutamicum\nprotein succinylation2-oxoglutarate dehydrogenase (ODH) complex
According to the results described above, the following novel mechanism for control of ODHC activity is suggested (Figure 4): in its unphosphorylated state, the 2-oxoglutarate dehydrogenase inhibitor protein OdhI binds to the E1 subunit (OdhA) of ODHC and thereby inhibits its activity. OdhI ...
We recently showed that the activity of the 2-oxoglutarate dehydrogenase complex (ODHC) in Corynebacterium glutamicum is controlled by a novel regulatory mechanism that involves a 15-kDa protein called OdhI and serine/threonine protein kinase G (PknG). In its unphosphorylated state, OdhI binds ...
Moreover, cancer-specific metabolic changes, such as those that occur subsequent to mutations in the genes encoding succinate dehydrogenase, fumarate hydratase or isocitrate dehydrogenase, can dysregulate specific 2OGDDs. This latter observation suggests that the role of 2OGDDs in cancer extends beyond...
During osmotic stress and hypoxia, the accumulation of proline (Pro) and alanine (Ala), respectively, promotes the transcriptional regulation of genes involved in their degradation, such as proline dehydrogenase (PDH), to compensate for their sudden increases in the cell under stress. Interesting...
Actinobacteria possess unique ways to regulate the oxoglutarate metabolic node. Contrary to most organisms in which three enzymes compose the 2-oxoglutarate dehydrogenase complex (ODH), actinobacteria rely on a two-in-one protein (OdhA) in which both the
Recent studies have revealed that the members of an ancient family of nonheme Fe2+/2-oxoglutarate-dependent dioxygenases (2-OGDO) are involved in the funct
2-Oxoglutarate dehydrogenaseOdhA2-Oxoglutarate dehydrogenase inhibitorFHA domainCorynebacterium glutamicumIn Corynebacterium glutamicum, the unphosphorylated 15-kDa OdhI protein inhibits the activity of the 2-oxoglutarate dehydrogenase complex (ODHc) by binding to OdhA, which in corynebacteria and mycobacteria ...
It has been suggested that this inborn error of catabolism of lysine, tryptophan, and hydroxylysine (27) may be due to 2-oxoadipate dehydrogenase deficiency, but such a defect has not been demonstrated directly. The yeast strains used in the present investigation are devoid of the LYS2 gene,...
For instance, glutamate dehydrogenase (GDH) downregulation has been shown to deplete 2-OG levels impairing the antioxidant enzyme GSH peroxidase 1, resulting in increased oxidative stress in lung and breast cancer cells [49]. Fumarate accumulation due to FH mutations associated with increased tumor ...