Glutamate production by Corynebacterium glutamicum : dependence on the oxoglutarate dehydrogenase inhibitor protein OdhI and protein kinase PknG . Appl. Microbiol. Biotechnol. 76 : 691 – 700 . doi: 10.1007/s00253-007-0933-9 .Schultz, C. , Niebisch, A. , Gebel, L. , and Bott, M. ( ...
cDNA, complementary DNA; gRNA, guide RNA; OGDH, oxoglutarate dehydrogenase; UAS, upstream activating sequence. Although the dOgdh-T2A-Gal4 mutant allele is suitable to test effects of variants in all tissues and cells that express dOgdh, this allele cannot determine the effect of variants in a...
Unlike the dehydrogenases of pyruvate and branched chain 2-oxo acids, the active site of the 2-oxoglutarate dehydrogenase component is not known to be phosphorylated. However, inActinobacteria, 2-oxoglutarate dehydrogenase is regulated by phosphorylation of itsprotein inhibitor, called GarA inM. tuber...
Moreover, cancer-specific metabolic changes, such as those that occur subsequent to mutations in the genes encoding succinate dehydrogenase, fumarate hydratase or isocitrate dehydrogenase, can dysregulate specific 2OGDDs. This latter observation suggests that the role of 2OGDDs in cancer extends beyond...
Actinobacteria possess unique ways to regulate the oxoglutarate metabolic node. Contrary to most organisms in which three enzymes compose the 2-oxoglutarate dehydrogenase complex (ODH), actinobacteria rely on a two-in-one protein (OdhA) in which both the
Mitochondrial 2-oxoglutarate (α-ketoglutarate) dehydrogenase complex (OGDHC), a key regulatory point of tricarboxylic acid (TCA) cycle, plays vital roles in multiple pathways of energy metabolism and biosynthesis. The catalytic mechanism and allosteric
The regulation of the 2-oxoglutarate dehydrogenase complex is central to intramitochondrial energy metabolism. In the present study, the active full-length... C Armstrong,JL? Anderson,R Denton - 《Biochemical Journal》 被引量: 20发表: 2014年 Formation of novel flavonoids in apple (Malusxdomestica...
2-Oxoglutarate dehydrogenaseOdhA2-Oxoglutarate dehydrogenase inhibitorFHA domainCorynebacterium glutamicumIn Corynebacterium glutamicum, the unphosphorylated 15-kDa OdhI protein inhibits the activity of the 2-oxoglutarate dehydrogenase complex (ODHc) by binding to OdhA, which in corynebacteria and mycobacteria ...
Effect of lysine succinylation on the regulation of 2-oxoglutarate dehydrogenase inhibitor, OdhI, involved in glutamate production in Corynebacterium glutamicum.2-oxoglutaratedehydrogenase(ODH)complexCorynebacteriumglutamicumOdhIglutamateproductionproteinIn Corynebacterium glutamicum, the activity of the 2-...
Calcium-mediated activation of one of these enzymes, 2-oxoglutarate dehydrogenase, has been shown to cause a marked decrease in the steady-state concentration of 2-oxoglutarate in both heart and liver mitochondria. In liver, 2-oxoglutarate is a potent inhibitor of oxalacetate transamination to ...