Environmental factors can impact oxidative phosphorylation and cellular respiration. Exposure to toxins, pollutants, or certain drugs can disrupt the electron transport chain and impair ATP synthesis. Additionally, alterations in nutrient availability, such as fasting or a high-fat diet, can influence oxi...
II respiratory activity7; cholangiocarcinoma cancer stem cells (CSCs) have a more efficient respiratory phenotype and depend on mitochondrial oxidative metabolism to maintain stemness8, while pancreatic cancer CSCs are dependent on oxidative phosphorylation (OXPHOS) with very limited metabolic plasticity9. ...
Glycolysis, oxidative phosphorylation, and the pentose phosphate pathway (PPP) are three primary branches of glucose metabolism, all of which are closely involved in radioresistance [9,10,11]. High glycolytic levels in tumor cells were found to be significantly correlated with resistance to chemoradiot...
1. Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China. 2. University of Chinese Academy of Sciences, Beijing, China. 3. Department of General Surgery or Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, S...
and then up-regulating the expression of HO-1 by promoting the transcriptional activity of Nrf2, exerting an anti-oxidative stress effect; On the other hand, AXT could deacetylates NF-κBp65 and inhibiting phosphorylation level of NF-κBp65 via activating SIRT1, subsequently reduce the level of...
The natural antioxidants can decrease oxidative stress-induced diabetic complications by direct scavenging of ROS & by inhibiting cell proliferation secondary to the protein phosphorylation. Antioxidants decrease the accumulation of GA3P and DHAP and block the formation of OS On the other hand by increa...
testosterone synthesis is stimulated by phosphatidylserine through a sequence in which phosphatidylserine induces the translocation of cytosolic Akt (protein kinase B) to the plasma membrane and interacts directly with Akt to alter its conformation and allow it to be activated via phosphorylation by mTOR...
Recently two members of the dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) DYRK1A and DYRK3, which play important role in body growth and brain physiology, have been demonstrated to promote cell survival by phosphorylating Sirt1 and inducing its deacetylase act...
Western blot analysis of tumor tissue indicated that (S)-crizotinib increased levels of γH2AX, Akt phosphorylation, and cle-caspase 3, whereas MK2206 alone was without effect (Fig. 8d). The combined treatment enhanced the levels of γH2AX and cle-caspase 3, and, as expected, inhibited Akt...
Although GCN2 is an eIF2α kinase, loss of GCN2 has no significant effect on myocardial eIF2αSer51 phosphorylation under basal conditions. However, while eIF2α phosphorylation and myocardial ATF4 and CHOP levels were significantly increased in the hearts of WT mice after Dox treatment, these ...