Oxidative phosphorylation (OXPHOS) is a multi-enzyme process located in the inner mitochondrial membrane (IMM) by which electrons from reduced metabolites are transferred to the ultimate electron acceptor oxygen, which is reduced to water. From:Journal of Molecular Biology,2018 ...
how vascular calcification in chronic kidney disease (CKD) is regulated by metabolic status remains poorly understood. Using a model of 5/6 nephrectomy, we demonstrated that the aortic tissues of CKD mice had a preference for using oxidative phosphorylation (OXPHOS). Both high phosphate and human...
Oxidative Phosphorylation is a mechanism for ATP synthesis in eukaryotes which involves the chemiosmotic coupling of electron transport and ATP synthesis.
On the dependence of nuclear oxidative phosphorylation on glycolysis in isolated rat thymus nuclei Inosine increased both the rate and level of ATP synthesis in isolated rat thymus nuclei. Adenine was rapidly incorporated into nuclear ATP but the hypoxanthine moiety of inosine was incorporated only slig...
Toward this end, and based on our previous work demonstrating the metabolic differences that exist between PaCSCs and non-PaCSCs, we describe herein a long-term and sustained cell culture system enriched in PaCSCs based on forced oxidative phosphorylation (OXPHOS), defined by electron transport ...
protein complexes the rate of oxidative phosphorylation is determined by the need for ATP (site of citric acid cycle & fatty acid oxidation) (permeable to small molecules) (site of oxidative phosphorylation) Net Reaction: 30 molecules of ATP are produced by the complete oxidation of glucose (...
Biological Energy Conservation: Oxidative Phosphorylation (Second Edition) Outline Studies in Biology by C. W. Jones Chapman and Hall; London; New York, 1981 78 pages. 2.45No abstract is available for this article.doi:10.1016/0014-5793(81)81248-3R.F.G. Booth...
Oxidative phosphorylation (OXPHOS) is the primary source of ATP in eukaryotes and serves as a mechanistic link between variation in genotypes and energetic phenotypes. While several physiological and anatomical factors may lead to increased aerobic capac
Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate produc
6. Mitochondria are the primary cellular source of reactive oxygen species (ROS) that arise as byproducts of mitochondrial oxidative phosphorylation. At high levels, ROS can cause detrimental effects by oxidizing cellular components such as proteins, lipids and nucleic acids, and prolonged ROS ...