Oxidative Phosphorylation Results from Cellular Respiration Mitochondrion Structure mitochondria oxidize carbon fuels to produce ATP and H2O this transformation involves electron and proton flow through several large protein complexes the rate of oxidative phosphorylation is determined by the need for ATP (site...
55004-1-AP), protein level, and aurora kinases and polo-like kinase 1 phosphorylation statue were also detected by western blot p-AKA/B/C (Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr
Targeting of both, oxidative phosphorylation and cell signaling partly explains the lethal effects of zelenirstat in select cancer types. While the prognostic value of the sensitivity score MISS-54 remains to be validated in patients, our findings continue to warrant the clinical development of zeleni...
polarization, we performed GSEA analysis. The results indicated upregulation of gene expression related to oxidative phosphorylation, and glycolysis and gluconeogenesis in the FPHA group (Fig.4D), with the core enrichment genes suggesting the involvement of FPHA in ATP synthesis and gluconeogenesis. In...
Taken together, Aβ resistant cells undergo a metabolic shift away from mitochondrial dependent oxidative phosphorylation towards aerobic glycolysis to meet energy requirements. However, the upstream triggers that promote this metabolic shift, and associated resistance to Aβ toxicity, are currently unknown...
The rate of oxidative phosphorylation by isolated mitochondria was found to be affected by red (650 m mu ) and far-red (725 m mu ) light. Esterification of adenosine diphosphate to adenosine tripliosphate by rat liver mitochondria is decreased by concomitant or prior irradiation with far-red ...
(Received 8 August 1988) (Revised manuscript received 26 April 1989) Key words: Oxidative phosphorylation; Slip; Leak; Membrane permeability; Stoichiometry change Contents Summary ... 12...文档格式:PDF | 页数:19 | 浏览次数:4 | 上传日期:2015-10-28 15:48:26 | 文档星级: Biochimica...
Many studies suggested that the apoptotic signal pathway is mediated by mitochondria with its critical role in cell survival for generation of ATP via oxidative phosphorylation (Wang et al., 2020a, 2020b; Yang et al., 2019). In addition to energy supplies, mitochondria regulate cell death ...
or phosphorylation of any component ofγ-secretase (data not shown). However, as the sensitivity of Western blotting assay could not be enough to detect the subtle change of modification, we are investigating the modification ofγ-secretase components using another method as well as other suggested...
Consistent with these findings, combined inhibition of the MEK/ERK pathway and mitochondrial oxidative phosphorylation effectively inhibited the growth of human and mouse leukemia cells in vitro. Our study provides a strong rational to target both ERK signaling and aberrant metabolism in oncogenic Ras-...