Emerging data are showing new and fundamental roles for microglia in the control of neuronal proliferation and differentiation, as well as in the formation of synaptic connections. While microglia have been studied for decades, a long history of experimental misinterpretation meant that their true ...
Microglia are the resident macrophages of the central nervous system (CNS), which sit in close proximity to neural structures and are intimately involved in brain homeostasis. The microglial population also plays fundamental roles during neuronal expansion and differentiation, as well as ...
Therapeutic benefit in neurological and psychiatric disorders can come from targeting bone marrow-derived myeloid cells to the CNS. Preclinical evidence is provided in animal models of Alzheimer's disease and Rett syndrome. Innate immune cells in the CNS (microglia, monocytes, macrophages and dendritic...
C. Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells. Mol. Cell. Neurosci. 25, 111–123 (2004). Article CAS PubMed Google Scholar Ichihara-Tanaka, K., Oohira, A., Rumsby, M. & Muramatsu, T. Neuroglycan C is a novel ...
Inflammatory infiltrates consisted mainly of CD4- and CD8-positive lymphocytes and were moderate in the perivascular cuffs and sparse in the lesion parenchyma. CD20-positive B cells were only rarely found and restricted to perivenous spaces. Mod- erate microglia activation and moderate macrophage ...
In this review, we highlight recent studies on microglial origin (from the embryonic yolk sac) and the factors regulating their differentiation and homeostasis upon brain invasion. Elegant experiments tracking microglia in the CNS allowed studies of their unique roles compared with other types of ...
In this review, we highlight recent studies on microglial origin (from the embryonic yolk sac) and the factors regulating their differentiation and homeostasis upon brain invasion. Elegant experiments tracking microglia in the CNS allowed studies of their unique roles compared with other types of ...
microgliamonocytemacrophagespinal cord injuryCycling myeloid cells (CMCs) are often detected from various tissues using single-cell RNA sequencing (scRNA-seq) datasets, however, their research value was not noticed before. For the first time, our study preliminarily revealed the origin, differentiation,...
(UBCs), Purkinje cells and GABAergic interneuron lineages, which reflects an origin from uncommitted cerebellum stem cells, followed by partial differentiation of transformed cells along diverse developmental lineages. group 4 MBs cell populations transcriptionally mirror the differentiated UBCs, UBC ...
(Extended Data Fig.5). We did not detect changes in the number of OLCs, microglia or astrocytes at P0 and P90 (Fig.4a–dand Extended Data Fig.5). To further investigate the transcriptional landscapes of glial and neuronal populations upon ablation, we performed single-nucleus RNA sequencing...