Organ-on-a-chipOrgan chipMicrofluidicsOphthalmologyEyeRetinaCorneaLensLacrimal glandRecent advances have driven the development of stem cell-derived, self-organizing, three-dimensional miniature organs, termed organoids, which mimic different eye tissues including the retina, cornea, and lens. Organoids ...
We compare the scales at which the two methods operate and briefly describe their achievements, followed by studies integrating organoids and organ-on-a-chip devices. Finally, we define implementation limitations and requirements for translation of the integrated devices, including determining the ...
Products for Organoid and Organ-on-a-chip Imaging 3D image stack of an angiogenesis model cultured using the OrganoPlate® system (MIMETAS). Nikon’s recently introduced AX / AX R series of confocal microscopes are applicable toward 3D cell culture imaging. The usability of the AX / AX R ...
organoidsorgan‐on‐a‐chipIn article number 1801363 Shiladitya Sengupta, Ali Khademhosseini and co‐workers show organ‐on‐a‐chip systems can provide high‐throughput platforms for drug development, which could potentially bridge the gap between 2D cell culture and animal models. With recent ...
Fourth, organs-on-a-chip provides an automated digital microfluidic platform with an array of electrodes that enables the automated culture of 3D organoid in media droplets, which provides a producible and precise method and reduces the variability compared to the traditional 3D culture system (Au,...
In the past decade, organoid and organ-on-a-chip cancer models have rapidly gained attention as alternatives to traditional two-dimensional cell cultures and murine models. However, they are still relatively “low throughput”—meaning that, similar to animal models, relatively low numbers of replic...
Commonorganoid culture methodsinclude submerged culture, gas-liquid interaction culture and co-culture. An organ-on-a-chip (OOC) is a cell culture device fabricated by microfluidics, usually consisting of a micro-perfused chamber with multilayered cellular structures, tissue interfaces, a physicochemical...
In this Review, we discuss how organ-on-a-chip technologies can recreate functions of organs, focusing on tissue barrier properties, parenchymal tissue function and multi-organ interactions, which are three key aspects of human physiology. Specific organ-on-a-chip systems are examined in terms of...
Wang Y, Wang L, Zhu Y, Qin J (2018) Human brain organoid-on-a-chip to model prenatal nicotine exposure. Lab Chip 18(6):851–860. https://doi.org/10.1039/C7LC01084B Article CAS PubMed Google Scholar Chou DB, Frismantas V, Milton Y, David R, Pop-Damkov P, Ferguson D, MacDo...
In article number 1801363 Shiladitya Sengupta, Ali Khademhosseini and co‐workers show organ‐on‐a‐chip systems can provide high‐throughput platforms for drug development, which could potentially bridge the gap between 2D cell culture and animal models. With recent breakthroughs in anticancer immunothe...