Editorial: 3D organoid and organ-on-a-chip and their applications for virology and antiviral researchdoi:10.3389/fmicb.2023.1266136MOLECULAR virologyYuebang YinLei XuSteinway, Steven NathanielFrontiers in Microbiology
Finally, we define implementation limitations and requirements for translation of the integrated devices, including determining the differentiation stage at which an organoid should be placed into an organ-on-a-chip device, providing perfusable vasculature within the organoid and overcoming limitations of ...
Products for Organoid and Organ-on-a-chip Imaging 3D image stack of an angiogenesis model cultured using the OrganoPlate® system (MIMETAS). Nikon’s recently introduced AX / AX R series of confocal microscopes are applicable toward 3D cell culture imaging. The usability of the AX / AX R ...
In the past decade, organoid and organ-on-a-chip cancer models have rapidly gained attention as alternatives to traditional two-dimensional cell cultures and murine models. However, they are still relatively “low throughput”—meaning that, similar to animal models, relatively low numbers of replic...
Organoids-on-a-chip Organ-on-a-chip is a miniaturized platform that utilizes microfluidic technology to culture cells on a microchip, simulating the microenvironment and functional characteristics of human organs, including cell-cell interactions, tissue structure, and physiological functions [66,67,68...
虽然已有研究报道, 通过在人视网膜类器官中用“organ-on-a-chip”装置模拟人体血管系统, 器官之间的联系, 使人视网膜类器官更加接近生理状态, 但是这跟视网膜正常的发育过程还有一定差距, 有待进一步改进[63]. 2.2 视网膜类器官用于模拟疾病发展过程研究致病机制 近年来, 已经建立了各种眼病的视网膜类器官. 这些...
虽然已有研究报道, 通过在人视网膜类器官中用“organ-on-a-chip”装置模拟人体血管系统, 器官之间的联系, 使人视网膜类器官更加接近生理状态, 但是这跟视网膜正常的发育过程还有一定差距, 有待进一步改进[63]. 2.2 视网膜类器官用于模拟疾病发展过程研究致病机制 近年来, 已经建立了各种眼病的视网膜类器官. 这些...
The most important thing about a cardiac organ on a chip is that it both promotes healthy cell growth and takes noninvasive readings of the activity of those cells over time. Cardiac cells contract in response to electronic signals from so-called pacemaker ...
A Organ-on-a-chip. Microfluidic-based single or multiple organ-on-a-chip platforms engineered to contain vascular flow and spatiotemporal mechanical and chemical gradients can be used to model complex interactions between the epithelium, stroma, and circulating immune components during virus infection....
Emerging technologies, including CRISPR-Cas9 gene editing, organ-on-a-chip systems, and advanced ECM-based scaffolds, are enhancing the precision of organoid models. These innovations facilitate better replication of the tumor microenvironment, supporting research in gynecological cancers such as cervical,...