Vascularized organoid-on-a-chip (VOoC) models achieve substance exchange in deep layers of organoids and provide a more physiologically relevant system in vitro. Common designs for VOoC primarily involve two categories: self-assembly of endothelial cells (ECs) to form microvessels and pre-patterned...
using an original and user-friendly microfluidic device and chip loading process. The reliability of our system was validated using spheroids generated from human fibroblasts and endothelial cells as well as 3D human blood vessel organoids (BVOs) generated from human-induced pluripotent stem cells (h...
1.(of a tissue) to develop or extend blood vessels or other fluid-bearing vessels or ducts. v.t. 2.to supply (an organ or tissue) with blood vessels. [1890–95] vas`cu•lar•i•za′tion,n. Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyr...
K.K.P. and D.E.I. were responsible for chip development and fabrication. M.I., S.M, A.D. and R.N. were responsible for software and hardware engineering and operation of the linking studies. R.P.-B., R.N., K.K.P. and D.E.I. were responsible for overseeing the entire eff...
Vascularized organoids on a chip: strategies for engineering organoids with functional vasculatureHuman organoids, self-organized and differentiated from homogenous pluripotent stem cells (PSC), replicate the key structural and functional characteristics of their in vivo counterparts. Despite the rapid ...
Tumor organoidsMicrovasculatureOrgan-on-a-chipRecent developments of organoids engineering and organ-on-a-chip microfluidic technologies have enabled the recapitulation of the major functions and architectures of microscale human tissue, including tumor pathophysiology. Nevertheless, there remain challenges in...
Vascularized Kidney Organoids on Chip for Efficacy and Toxicity Testing of Somatic Genome Editingdoi:10.1681/ASN.20213210S1432aNavin R. GuptaMassachusetts General Hospital, Boston, MA;Kayla J. WolfHarvard University Wyss Institute for Biologically Inspired Engineering, Boston, MA.Krishna P. Maremanda...
It also explores the potential for a novel organoid chip vascularization approach that combines organoids and organ chips to generate better vascularization chips.Hongze YinYue WangNa LiuSongyi ZhongLong LiQuan ZhangZeyang LiuTao YueCyborg and Bionic Systems...
organoidsorgan‐on‐a‐chipvasculatureHuman stemヽellヾerived organoids have provided new opportunities to model biological processes and recapitulate organ development. However, organoid systems lack perfusable vascular networks to deliver nutrients and drugs. In article number 2002974, Boyang Zhang and ...
An automated microfluidic platform integrating functional vascularized organoids-on-chipdoi:10.1101/2021.12.29.474327Clement QuintardGustav JonssonCamille LaporteXavier Gidrol