TF65/Rela and Relb are known to play important roles in inflammation, immunity, differentiation, cell proliferation, and apoptosis. Further, small Mafs are essential for oxidative stress response. In response to DNA damage or other cellular stresses, Cdkn1a/p21 can be induced to arrest the cell...
The WC-pyrimidine strand is erased from ΔLk = +1 image for visualisation purposes. c Violin plot of non-bonded interactions for the triplex-binding site (ΔEbind;L), showing the relative contributions from in-plane base interactions (e.g. WC and Hoogsteen hydrogen bonds) (green), ...
to “hard” metal ions. Therefore, use of PSs also permits the identification of metal-ion binding sites in the biological systems. The PS-inter-nucleotide linkage is considerably more stable than the phosphodiester bond toward nucleases, and this feature makes it useful for cell culture and in ...
to “hard” metal ions. Therefore, use of PSs also permits the identification of metal-ion binding sites in the biological systems. The PS-inter-nucleotide linkage is considerably more stable than the phosphodiester bond toward nucleases, and this feature makes it useful for cell culture and in ...
Alternative splicing is a complex process that provides a high diversity of proteins from a limited number of protein-coding genes. It is governed by multiple regulatory factors, including RNA-binding proteins (RBPs), that bind to specific RNA sequences
5.9. Milasen Milasen is a personalized ASO that was specifically designed to treat a six-year-old child suffering from neuronal ceroid lipofuscinosis 7 (CLN7) that affects the central nervous system (Table 2). This rare and fatal neurodegenerative condition, also known as Batten disease, leads...
based on their targeting, a sequence on the template or the coding strand, respectively [30]. Coding PPRH, apart from targeting and binding DNA, can target mRNA and modify post-transcriptional processes [31]. These hairpin molecules have a broad spectrum of applications and have been previously...
With this strategy, the long PEG chain was used to confer longevity of the whole system when in circulation, once in oxygen-deprived regions the azobenzene group could lead to the detachment of the PEG chain, addressing the well-known "PEG dilemma". Indeed, it has been widely reported that...