Inclusion criteria were patients who had been diagnosed with schizophrenia or schizoaffective disorder (following DSM-IV guidelines) and were being treated with OLZ. A prospective, observational, open-study design was implemented. In line with the literature, patients were only included if t...
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Therefore, the development of strategies to induce the conversion of the crystalline into the (co-)amorphous form of drugs, and maintenance of such state, is of paramount importance. The conversion may be achieved directly during the manufacture of the dosage form, the so-called in situ ...
Introduction Active pharmaceutical ingredients (APIs) are exposed to water in many pharmaceutical processes, such as wet granulation or wet extrusion, which can lead to the conversion of the anhydrate form into the hydrate form during processing. The subsequent drying processes may induce the ...