Normal controls were excluded if presented with past history or current diagnosis of psychiatric disorders as documented by SCID-IV. At the time of enrollment, all patients were experiencing acute exacerbation of psychosis requiring hospitalization. Nine patients were diagnosed with schizophreniform ...
Patients in the triplet group received the following: olanzapine 5 mg PO days 1–3, tropisetron 5 mg iv days 1–3, and dexamethasone 10 mg iv days 1–3. The aprepitant group had a half dosage of dexamethasone besides tropisetron hydrochloride and aprepitant, since the function of CYP3A4 ...
(EPS) liability, using a catalepsy test, (iii) dopamine efflux in the medial prefrontal cortex and the nucleus accumbens, using in vivo microdialysis in freely moving animals and (iv) cortical N-methyl-D-aspartate (NMDA) receptor-mediated transmission, using intracellular electrophysiological ...
Fourteen first-episode DSM-IV schizophrenia patients were randomly allocated to receive either famotidine (40 mg/day, n=7) or placebo ( n=7) in addition to olanzapine (10 mg/day) for 6 weeks. All patients completed the trial. Patients in both groups showed a similar increase in body ...
All patients had a DSM-IV or DSM-IV-TR diagnosis of schizophrenia (n = 2026) or schizoaffective disorder (n = 28) and were between the ages of 18 and 75. Exclusion criteria included significant suic...Detke HC, McDonnell DP, Andersen SW, Watson SB. 160-week interim results from ...
Pts in both arms received 1) a 5-HT3receptor antagonist (palonosetron 0.25 mg IV or ondansetron 8-16 mg IV or 16-24 mg PO,) on day one, 2) dexamethasone (12 mg PO, day one followed by 8 mg PO, days 2-4), and 3) olanzapine (10 mg/day PO, days 1 to 4). On Day 1, ...
Inclusion criteria were patients who had been diagnosed with schizophrenia or schizoaffective disorder (following DSM-IV guidelines) and were being treated with OLZ. A prospective, observational, open-study design was implemented. In line with the literature, patients were only included if t...
All subjects were chronically ill and were diagnosed with schizophrenia according to DSM-IV (American Psychiatric Associa- tion, 1994). Subjects were free of active medical prob- lems or substance abuse during the six months preced- ing this study. Two patients participated in both the olanzapine...
Psychiatric and medical diag- noses were obtained from clinical records; the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) (American Psychiatric Associa- tion, 1987) were used at each study site. For cases where more than one diagnosis was listed...
(EPS) liability, using a catalepsy test, (iii) dopamine efflux in the medial prefrontal cortex and the nucleus accumbens, using in vivo microdialysis in freely moving animals and (iv) cortical N-methyl-D-aspartate (NMDA) receptor-mediated transmission, using intracellular electrophysiological ...