Pts in both arms received 1) a 5-HT3receptor antagonist (palonosetron 0.25 mg IV or ondansetron 8-16 mg IV or 16-24 mg PO,) on day one, 2) dexamethasone (12 mg PO, day one followed by 8 mg PO, days 2-4), and 3) olanzapine (10 mg/day PO, days 1 to 4). On Day 1, ...
Normal controls were excluded if presented with past history or current diagnosis of psychiatric disorders as documented by SCID-IV. At the time of enrollment, all patients were experiencing acute exacerbation of psychosis requiring hospitalization. Nine patients were diagnosed with schizophreniform ...
(EPS) liability, using a catalepsy test, (iii) dopamine efflux in the medial prefrontal cortex and the nucleus accumbens, using in vivo microdialysis in freely moving animals and (iv) cortical N-methyl-D-aspartate (NMDA) receptor-mediated transmission, using intracellular electrophysiological ...
Initially, the staff treated for a presumed dystonic reaction to olanzapine and administered diphenhydramine 25 mg IV, diazepam 2 mg IV, midazolam 5 mg IV, and benztropine 1 mg IV without improvement. It was later determined that the patient took 16 mg of buprenorphine SL daily. With this ...
All subjects were chronically ill and were diagnosed with schizophrenia according to DSM-IV (American Psychiatric Associa- tion, 1994). Subjects were free of active medical prob- lems or substance abuse during the six months preced- ing this study. Two patients participated in both the olanzapine...
Inclusion criteria were patients who had been diagnosed with schizophrenia or schizoaffective disorder (following DSM-IV guidelines) and were being treated with OLZ. A prospective, observational, open-study design was implemented. In line with the literature, patients were only included if t...
Fourteen first-episode DSM-IV schizophrenia patients were randomly allocated to receive either famotidine (40 mg/day, n=7) or placebo ( n=7) in addition to olanzapine (10 mg/day) for 6 weeks. All patients completed the trial. Patients in both groups showed a similar increase in body ...
All patients had a DSM-IV or DSM-IV-TR diagnosis of schizophrenia (n = 2026) or schizoaffective disorder (n = 28) and were between the ages of 18 and 75. Exclusion criteria included significant suic...Detke HC, McDonnell DP, Andersen SW, Watson SB. 160-week interim results from ...
Psychiatric and medical diag- noses were obtained from clinical records; the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) (American Psychiatric Associa- tion, 1987) were used at each study site. For cases where more than one diagnosis was listed...
(iv) all of R1-R4are CH3; (v) two of R1-R4are CH3, one of R1-R4is C6H5CH2, and one of R1-R4is an alkyl chain of seven carbon atoms or less; (vi) two of R1-R4are CH3, one of R1-R4is C6H5CH2, and one of R1-R4is an alkyl chain of nineteen carbon atoms or more;...