OlanzapineAn abstract of the article "Post-injection delirium/sedation syndrome following injection of olanzapine pamoate: A new syndrome in emergency psychiatry," by K. Buts and colleagues is presented.Reactions Weekly
Anhydrous olanzapine was added to water with or without those polymers prior to extrusion with microcrystalline cellulose. Assessment of olanzapine conversion was made by XRP-Diffraction; FTIR spectroscopy; calorimetry (DSC) and microscopy (SEM for crystal size and shape). The addition of water ...
Therefore, the development of strategies to induce the conversion of the crystalline into the (co-)amorphous form of drugs, and maintenance of such state, is of paramount importance. The conversion may be achieved directly during the manufacture of the dosage form, the so-called in situ ...