Olanzapine is available as oral tablets, orally disintegrating tablets, or an injection that is given into a muscle (intramuscular [IM]). The olanzapine IM preparation is only for acute agitation associated with schizophrenia and bipolar I mania in adults. ...
Oral:Initial dose: 5 mg orally per day In combination with fluoxetine: Initial dose: 2.5 to 5 mg orally per day Dose escalation should be performed with cautionParenteral: Immediate-release IM: Initial dose: 2.5 mg IM Extended-release IM suspension: Initial dose: 150 mg IM every 4 weeks...
Olanzapine versus haloperidol in transitioning from intramuscular (IM) to oral therapydoi:10.1016/S0924-977X(01)80356-4P. WrightK.M. MeehanM. BirkettS.R. DavidA. BreierElsevier B.V.European Neuropsychopharmacology
and from about two weeks to about twelve weeks. Additional time periods of efficacy are described herein. This allows for improved patient compliance with enhanced therapeutic outcomes. Moreover, injectable formulations of olanzapine result in a significantly shorter response time as compared to oral ad...
Analysis of randomized clinical trials with oral and intramuscular (IM) olanzapine in bipolar-affective disorders based on EBM criteria and therapeutic effect calculation - Schizophrenia Researchdoi:10.1016/S0920-9964(03)80449-8J.CzekallaandU.
Bergstrom RF, Mitchell M, Jewell H, Richards J, Hatcher B. Examination of the safety, tolerance and pharmacokinetics of intramuscular (IM) olanzapine compared to oral olanzapine in healthy subjects. Schizophr Res. 1999;36:305-306.
In addition, long-term use of oral olanzapine has been shown to maintain treatment response in patients with schizophrenia. If used for an extended period, periodically reassess need for continued maintenance therapy.Acute Agitation associated with Schizophrenia IM, Short-acting Olanzapine ...
Cardiac conduction in females and males under intramuscular (IM) and oral olanzapine from schizophrenia clinical trials ECGsdoi:10.1016/S0924-977X(02)80415-1J. Czekalla and C. Beasley Jr. and S. David and P.H. Berg and V. Stauffer and C. Boylan...
In addition to stabilization, in situ amorphization techniques offer the possibility to discard the production of amorphous solid dispersions prior to the manufacture of oral dosage forms, thus resulting in manufacturing savings and reduced logistic restrictions. Examples of investigations on in situ co-...