Olanzapine IM injection Olanzapine IM is a short-acting formulation that may be given to adults with schizophrenia or bipolar I mania if they have become agitated. The usual dosage of olanzapine IM is 10 mg as a single dose. Smaller dosages (5 mg or 7.5 mg) can be given if these are ...
hypovolemia, and dehydration, hyperglycemia may occur and in some cases may be extreme, resulting in ketoacidosis, hyperosmolar coma, or death; IM administration of greater than 1 injection is associated with substantial orthostatichypotension(33%); maintain patient in recumbent position and monitor...
Extended-release IM injection: Very common (10% or more): Plasma prolactin level elevation (up to 30%) Uncommon (0.1% to 1%): Gynecomastia/male breast enlargement[Ref]In clinical studies, changes in prolactin levels were found to be statistically significantly different based on dose, higher ...
(Zyprexa Zydis) is asolid dosage form that immediately disintegrates when exposedto saliva. This product is useful for elderly patients whohave difficulty in swallowing. An injectable form, olanzapinefor injection (Zyprexa IM), is indicated for agitation associatedwith schizophrenia or bipolar I mania...
A dose of 5 mg/injection should be considered for geriatric patients or when other clinical factors warrant.A lower dose of 2.5 mg/injection should be considered for patients who otherwise might be debilitated, be predisposed to hypotensive reactions, or be morepharmacodynamically sensitive to olan...
A dose-response relationship for IM olanzapine in the reduction of agitation was assessed by measuring the reduction in Positive and Negative Syndrome Scale Excited Component (PANSS-EC) scores 2 hours after the first injection. Safety was assessed by recording adverse events and with extrapyramidal ...
(Zyprexa Zydis) is asolid dosage form that immediately disintegrates when exposedto saliva. This product is useful for elderly patients whohave difficulty in swallowing. An injectable form, olanzapinefor injection (Zyprexa IM), is indicated for agitation associatedwith schizophrenia or bipolar I mania...
Introduction: Intramuscular (IM) olanzapine has been approved for the management of acute agitation/psychosis secondary to schizophrenia, bipolar disorder, and dementia, in a dose not to exceed 10 mg per injection and 30 mg per day. Many other clinical situations exist in which patients are ...
Single- and multiple-dose pharmacokinetics, safety and tolerability profiles of olanzapine long-acting injection (LAI): an open-label, multicenter, non-randomized study in patients with schizophrenia . Clin Ther 2013; 35 :1890–1908Mitchell M, Kothare P, Bergstrom R, Zhao F, Jen KY, Walker D...
positive score, the BARS score, and the DIEPSS total score was significantly greater in the IM olanzapine injection group compared with the levomepromazine injection group.The results of this study suggest that agitated elderly patients rapidly respond to IM olanzapine and IM levome...